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Tclin
SSTR4
Somatostatin receptor type 4

Protein Summary
Description
Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells. Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255008
  • ENSP00000255008
  • ENSG00000132671

Symbol
  • SS4R
  • SS4-R
  • SS-4-R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.83
biological process
0.82
ligand (chemical)
0.76
tissue sample
0.76
cell line
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 211.04   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 207   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 211.04   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 80
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Pathways (12)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Protein-Protein Interactions (273)
1 – 10 of 273
SST
Tbio
Novelty: 0.0000732
Score: 0.995
Data Source: STRINGDB
CORT
Tbio
Novelty: 0.0034818
Score: 0.969
Data Source: STRINGDB
POMC
Tbio
Novelty: 0.00002654
Score: 0.954
Data Source: STRINGDB
NPB
Tdark
Novelty: 0.00254878
Score: 0.941
Data Source: STRINGDB
NPW
Tbio
Novelty: 0.01251552
Score: 0.938
Data Source: STRINGDB
NPY
Tbio
Novelty: 0.00014761
Score: 0.937
Data Source: STRINGDB
HTR5A
Tchem
Family: GPCR
Novelty: 0.01826019
Score: 0.936
Data Source: STRINGDB
PPY
Tbio
Novelty: 0.00056678
Score: 0.934
Data Source: STRINGDB
CNR1
Tclin
Family: GPCR
Novelty: 0.00017618
Score: 0.933
Data Source: STRINGDB
GAL
Tbio
Novelty: 0.00057698
Score: 0.932
Data Source: STRINGDB
Publication Statistics
PubMed Score  211.04

PubMed score by year
PubTator Score  65.02

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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