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Tclin
CD52
CAMPATH-1 antigen

Protein Summary
Description
May play a role in carrying and orienting carbohydrate, as well as having a more specific role.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374213
  • ENSP00000363330
  • ENSG00000169442

Symbol
  • CDW52
  • HE5
  • HE5
  • CDW52
  • EDDM5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease
0.88
small molecule perturbation
0.86
PubMedID
0.78
gene perturbation
0.56
cell line
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 692.2   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 680   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 692.2   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 680   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (173)
FCGR3B
Tbio
Novelty:  0.000429
Score:  0.935
Data Source:  STRINGDB
VNN2
Tbio
Novelty:  0.02286648
Score:  0.925
Data Source:  STRINGDB
BST1
Tbio
Family:  Enzyme
Novelty:  0.01329061
Score:  0.92
Data Source:  STRINGDB
FOLR2
Tchem
Novelty:  0.00751372
Score:  0.912
Data Source:  STRINGDB
CEACAM5
Tbio
Novelty:  0.00007291
Score:  0.912
Data Source:  STRINGDB
IZUMO1R
Tbio
Novelty:  0.02670576
Score:  0.91
Data Source:  STRINGDB
CD109
Tbio
Novelty:  0.01280272
Score:  0.907
Data Source:  STRINGDB
ULBP2
Tbio
Novelty:  0.01604318
Score:  0.906
Data Source:  STRINGDB
THY1
Tbio
Novelty:  0.00032846
Score:  0.906
Data Source:  STRINGDB
XPNPEP2
Tchem
Family:  Enzyme
Novelty:  0.01453123
Score:  0.905
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
2
2
90.6
monocyte percentage of leukocytes
2
2
2
87.6
appendicular lean mass
2
1
2
78.9
eosinophil count
2
1
2
63.7
eosinophil percentage of leukocytes
1
1
1
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
90.6
monocyte percentage of leukocytes
2
87.6
appendicular lean mass
2
78.9
eosinophil count
2
63.7
eosinophil percentage of leukocytes
1
54.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD52 molecule
VGNC:5012
736829
Macaque
CD52 molecule
714429
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD52 molecule
Macaque
CD52 molecule
Publication Statistics
PubMed Score 692.20
PubMed score by year
PubTator Score 518.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title