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Tclin
RRM2
Ribonucleoside-diphosphate reductase subunit M2

Protein Summary
Description
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling. This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304567
  • ENSP00000302955
  • ENSG00000171848
  • ENST00000360566
  • ENSP00000353770
  • ENST00000615152
  • ENSP00000484183
  • ENST00000641198
  • ENSP00000493399

Symbol
  • RR2
  • R2
  • RR2
  • RR2M
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
0.96
transcription factor perturbation
0.96
gene perturbation
0.93
transcription factor binding site profile
0.85
microRNA
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 897.76   (req: < 5)
Gene RIFs: 80   (req: <= 3)
Antibodies: 270   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 897.76   (req: >= 5)
Gene RIFs: 80   (req: > 3)
Antibodies: 270   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
1
1
5.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
5.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ribonucleotide reductase regulatory subunit M2
703138
Mouse
MGI:98181
20135
Rat
RGD:1598310
362720
Dog
ribonucleotide reductase regulatory subunit M2
VGNC:45761
482963
Horse
ribonucleotide reductase regulatory subunit M2
VGNC:22583
100072410
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ribonucleotide reductase regulatory subunit M2
Mouse
Rat
Dog
ribonucleotide reductase regulatory subunit M2
Horse
ribonucleotide reductase regulatory subunit M2
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P31350-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (31)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
G1/S Transition
Reactome
G1/S-Specific Transcription
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
G1/S Transition
G1/S-Specific Transcription
Gene expression (Transcription)
Protein-Protein Interactions (353)
1 – 10 of 353
RRM2B
Tbio
Family: Enzyme
Novelty: 0.00817283
p_int: 1
Score: 0.972
Data Source: BioPlex,STRINGDB
FZR1
Tbio
Novelty: 0.01599606
p_int: 0.999999994
p_ni: 6e-9
Score: 0.836
Data Source: BioPlex,STRINGDB
INPPL1
Tchem
Family: Enzyme
Novelty: 0.00634126
p_int: 0.999919592
p_ni: 0.000080408
Score: 0.702
Data Source: BioPlex,STRINGDB
RRM1
Tclin
Family: Enzyme
Novelty: 0.00083196
p_int: 0.998967162
p_ni: 0.001032838
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
ANAPC4
Tbio
Family: Enzyme
Novelty: 0.28937094
p_int: 0.958913468
p_ni: 0.03833304
p_wrong: 0.002753492
Score: 0.753
Data Source: BioPlex,STRINGDB
FAF2
Tbio
Novelty: 0.03048598
p_int: 0.950946996
p_ni: 0.049053004
Score: 0.332
Data Source: BioPlex,STRINGDB
CDC27
Tbio
Novelty: 0.00589846
p_int: 0.903598531
p_ni: 0.096399215
p_wrong: 0.000002253
Score: 0.588
Data Source: BioPlex,STRINGDB
SPAG9
Tbio
Family: Enzyme
Novelty: 0.00527315
p_int: 0.888713814
p_ni: 0.111286186
Score: 0.239
Data Source: BioPlex,STRINGDB
CDK1
Tchem
Family: Kinase
Novelty: 0.00040776
Score: 0.991
Data Source: STRINGDB
TOP2A
Tclin
Family: Enzyme
Novelty: 0.00122788
Score: 0.977
Data Source: STRINGDB
Publication Statistics
PubMed Score  897.76

PubMed score by year
PubTator Score  825.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer