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Tbio
HOXC13
Homeobox protein Hox-C13

Protein Summary
Description
Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes (By similarity). This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the development of hair, nail, and filiform papilla. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000243056
  • ENSP00000243056
  • ENSG00000123364

Symbol
  • HOX3G
  • HOX3
  • ECTD9
  • HOX3G
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.76
PubMedID
0.66
biological process
0.62
small molecule perturbation
0.62
transcription factor binding site profile
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.92   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.92   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
FOXN1
Tbio
Family:  TF
Novelty:  0.00338433
Score:  0.858
Data Source:  STRINGDB
HOXC11
Tbio
Family:  TF
Novelty:  0.03595579
Score:  0.642
Data Source:  STRINGDB
MEIS1
Tbio
Family:  TF
Novelty:  0.00480433
Score:  0.633
Data Source:  STRINGDB
FOXQ1
Tbio
Family:  TF
Novelty:  0.01816638
Score:  0.629
Data Source:  STRINGDB
FOXN2
Tbio
Family:  TF
Novelty:  0.06019241
Score:  0.628
Data Source:  STRINGDB
KRT32
Tdark
Novelty:  1.12077627
Score:  0.616
Data Source:  STRINGDB
DSG4
Tbio
Novelty:  0.01599371
Score:  0.606
Data Source:  STRINGDB
KRT84
Tdark
Novelty:  0.23563823
Score:  0.592
Data Source:  STRINGDB
DDX10
Tbio
Family:  Enzyme
Novelty:  0.03272208
Score:  0.57
Data Source:  STRINGDB
PSIP1
Tchem
Family:  Epigenetic
Novelty:  0.00216601
Score:  0.57
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
12
19
54
98.5
waist circumference
2
15
15
97.6
waist-hip ratio
7
17
21
97.6
BMI-adjusted waist circumference
7
15
26
97.3
spine bone size
1
1
1
82.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
54
98.5
waist circumference
15
97.6
waist-hip ratio
21
97.6
BMI-adjusted waist circumference
26
97.3
spine bone size
1
82.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
homeobox C13
VGNC:5419
467008
Mouse
MGI:99560
15422
Rat
RGD:1563984
315337
Dog
homeobox C13
VGNC:41758
486503
Horse
homeobox C13
VGNC:18849
100062304
Species
Name
OMA
EggNOG
Inparanoid
Chimp
homeobox C13
Mouse
Rat
Dog
homeobox C13
Horse
homeobox C13
Publication Statistics
PubMed Score 65.92
PubMed score by year
PubTator Score 630.06
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title