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Tbio
HOXC12
Homeobox protein Hox-C12

Protein Summary
Description
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000243103
  • ENSP00000243103
  • ENSG00000123407

Symbol
  • HOC3F
  • HOX3F
  • HOX3
  • HOC3F
  • HOX3F
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.59
protein domain
0.58
transcription factor binding site profile
0.53
cell line
0.51
transcription factor
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.07   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.07   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (31)
KRT32
Tdark
Novelty:  1.12077627
Score:  0.709
Data Source:  STRINGDB
KRT35
Tbio
Novelty:  0.01111091
Score:  0.656
Data Source:  STRINGDB
SIX2
Tbio
Family:  TF
Novelty:  0.01046481
Score:  0.566
Data Source:  STRINGDB
FOXN1
Tbio
Family:  TF
Novelty:  0.00338433
Score:  0.538
Data Source:  STRINGDB
HOXC13
Tbio
Family:  TF
Novelty:  0.01749797
Score:  0.514
Data Source:  STRINGDB
THSD7A
Tbio
Novelty:  0.01515873
Score:  0.505
Data Source:  STRINGDB
FBXL4
Tbio
Novelty:  0.04286856
Score:  0.505
Data Source:  STRINGDB
RAB9A
Tbio
Family:  Enzyme
Novelty:  0.07006531
Score:  0.502
Data Source:  STRINGDB
RAB19
Tbio
Family:  Enzyme
Novelty:  0.15847208
Score:  0.501
Data Source:  STRINGDB
ISL1
Tbio
Family:  TF
Novelty:  0.00169431
Score:  0.492
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
WikiPathways
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
WikiPathways
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
WikiPathways
TYROBP Causal Network
WikiPathways
Endochondral Ossification
Name
Explore in Pharos
Explore in Source
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
TYROBP Causal Network
Endochondral Ossification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
12
20
55
98.5
waist circumference
2
16
16
97.7
waist-hip ratio
7
18
22
97.6
BMI-adjusted waist circumference
7
15
26
97.3
spine bone size
1
1
1
82.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
55
98.5
waist circumference
16
97.7
waist-hip ratio
22
97.6
BMI-adjusted waist circumference
26
97.3
spine bone size
1
82.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
homeobox C12
VGNC:5418
467009
Macaque
homeobox C12
704201
Mouse
MGI:96194
15421
Rat
RGD:1310539
300262
Dog
homeobox C12
VGNC:41757
486502
Species
Name
OMA
EggNOG
Inparanoid
Chimp
homeobox C12
Macaque
homeobox C12
Mouse
Rat
Dog
homeobox C12
Publication Statistics
PubMed Score 7.07
PubMed score by year
PubTator Score 3.86
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title