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Tbio
HOXA13
Homeobox protein Hox-A13

Protein Summary
Description
Sequence-specific, AT-rich binding transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Expansion of a polyalanine tract in the encoded protein can cause hand-foot-uterus syndrome, also known as hand-foot-genital syndrome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222753
  • ENSP00000222753
  • ENSG00000106031
  • ENST00000649031
  • ENSP00000497112

Symbol
  • HOX1J
  • HOX1
  • HOX1J
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.9
cell type or tissue
0.76
microRNA
0.64
phenotype
0.64
PubMedID
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 156.35   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 156.35   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
MEIS1
Tbio
Family:  TF
Novelty:  0.00480433
Score:  0.724
Data Source:  STRINGDB
MEIS2
Tbio
Family:  TF
Novelty:  0.01393828
Score:  0.702
Data Source:  STRINGDB
HOXA11
Tbio
Family:  TF
Novelty:  0.00745145
Score:  0.668
Data Source:  STRINGDB
BMP7
Tbio
Novelty:  0.00049424
Score:  0.637
Data Source:  STRINGDB
RPS16
Tbio
Novelty:  0.00261983
Score:  0.629
Data Source:  STRINGDB
PBX1
Tbio
Family:  TF
Novelty:  0.00329442
Score:  0.583
Data Source:  STRINGDB
HOXA10
Tbio
Family:  TF
Novelty:  0.00324357
Score:  0.558
Data Source:  STRINGDB
ALDH1A2
Tchem
Family:  Enzyme
Novelty:  0.00461371
Score:  0.556
Data Source:  STRINGDB
RPL13A
Tbio
Novelty:  0.00503698
Score:  0.537
Data Source:  STRINGDB
MEIS3
Tbio
Family:  TF
Novelty:  0.09265838
Score:  0.53
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (39)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
8
13
96.4
BMI-adjusted waist-hip ratio
9
13
20
96
waist-hip ratio
5
15
16
91.3
diastolic blood pressure
5
7
10
91.1
waist circumference
1
7
7
86.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
13
96.4
BMI-adjusted waist-hip ratio
20
96
waist-hip ratio
16
91.3
diastolic blood pressure
10
91.1
waist circumference
7
86.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
homeobox A13
VGNC:4391
472326
Mouse
MGI:96173
15398
Rat
RGD:1562483
500129
Dog
homeobox A13
VGNC:54311
482375
Cow
homeobox A13
VGNC:53648
787194
Species
Name
OMA
EggNOG
Inparanoid
Chimp
homeobox A13
Mouse
Rat
Dog
homeobox A13
Cow
homeobox A13
Publication Statistics
PubMed Score 156.35
PubMed score by year
PubTator Score 75.60
PubTator score by year
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Related Publications
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PMID
Year
Title