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Tbio
HOXD3
Homeobox protein Hox-D3

Protein Summary
Description
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in the regulation of cell adhesion processes. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249440
  • ENSP00000249440
  • ENSG00000128652
  • ENST00000410016
  • ENSP00000386498

Symbol
  • HOX1D
  • HOX4A
  • HOX4
  • HOX1D
  • HOX4A
  • Hox-4.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
biological process
0.68
cell type or tissue
0.68
disease perturbation
0.62
kinase perturbation
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.92   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 191   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.92   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.3
85.5
ovarian serous carcinoma
3
1
0
1.1
85.5
2
1
0
1.1
83.4
1
1
1
63.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
85.5
ovarian serous carcinoma
0
1.1
85.5
0
1.1
83.4
1
63.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
homeobox D3
459764
Mouse
MGI:96207
15434
Rat
RGD:1588601
288152
Dog
homeobox D3
VGNC:41765
488417
Horse
homeobox D3
VGNC:18853
100053542
Species
Name
OMA
EggNOG
Inparanoid
Chimp
homeobox D3
Mouse
Rat
Dog
homeobox D3
Horse
homeobox D3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P31249-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Activation of HOX genes during differentiation (R-HSA-5619507)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Developmental Biology
Gene Ontology Terms (20)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred by Curator (IC)
NTNU_SB
Protein-Protein Interactions (62)
1 – 10 of 62
HIST1H2AJ
Tdark
Novelty: 0.70360784
Score: 0.912
Data Source: STRINGDB
POLR2I
Tbio
Family: Enzyme
Novelty: 0.03100605
Score: 0.91
Data Source: STRINGDB
HIST1H2BM
Tdark
Novelty: 0.70393417
Score: 0.91
Data Source: STRINGDB
POLR2F
Tbio
Family: Enzyme
Novelty: 0.03787683
Score: 0.906
Data Source: STRINGDB
HIST1H2BA
Tbio
Novelty: 0.02431803
Score: 0.903
Data Source: STRINGDB
H2AFV
Tbio
Novelty: 0.03561635
Score: 0.902
Data Source: STRINGDB
H2AFZ
Tbio
Novelty: 0.00222512
Score: 0.902
Data Source: STRINGDB
HIST2H2BE
Tbio
Novelty: 0.00024381
Score: 0.901
Data Source: STRINGDB
POLR2A
Tbio
Family: Enzyme
Novelty: 0.00188323
Score: 0.9
Data Source: STRINGDB
POLR2H
Tbio
Family: Enzyme
Novelty: 0.04008409
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  55.92

PubMed score by year
PubTator Score  30.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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