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Tclin
SRD5A2
3-oxo-5-alpha-steroid 4-dehydrogenase 2

Protein Summary
Description
Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology. This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH). [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000622030
  • ENSP00000477587
  • ENSG00000277893
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.84
biological process
0.67
cellular component
0.63
chemical
0.61
disease
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 352.7   (req: < 5)
Gene RIFs: 150   (req: <= 3)
Antibodies: 225   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 352.7   (req: >= 5)
Gene RIFs: 150   (req: > 3)
Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 338
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
92.4
Alopecia
1
2
2
69.1
1
1
0
1.7
49.7
blood metabolite measurement
2
1
3
37.5
blood protein measurement
1
1
1
25.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
92.4
Alopecia
2
69.1
0
1.7
49.7
blood metabolite measurement
3
37.5
blood protein measurement
1
25.4
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2150380
94224
Rat
RGD:621480
64677
Dog
steroid 5 alpha-reductase 2
VGNC:46794
403715
Cow
steroid 5 alpha-reductase 2
VGNC:35272
527024
Pig
steroid 5 alpha-reductase 2
397048
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
steroid 5 alpha-reductase 2
Cow
steroid 5 alpha-reductase 2
Pig
steroid 5 alpha-reductase 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P31213-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (28)
Androgen biosynthesis (R-HSA-193048)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Androgen biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroid hormones
Reactome
Metabolism of steroids
Name
Explore in Pharos
Explore in Source
Androgen biosynthesis
Metabolism
Metabolism of lipids
Metabolism of steroid hormones
Metabolism of steroids
Gene Ontology Terms (32)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (87)
1 – 10 of 87
CLPTM1
Tbio
Novelty: 0.06426049
p_int: 0.994167419
p_ni: 0.005832581
Data Source: BioPlex
HSD17B3
Tchem
Family: Enzyme
Novelty: 0.00666322
Score: 0.978
Data Source: STRINGDB
CYP17A1
Tclin
Family: Enzyme
Novelty: 0.00065091
Score: 0.973
Data Source: STRINGDB
HSD3B2
Tclin
Family: Enzyme
Novelty: 0.00711552
Score: 0.969
Data Source: STRINGDB
AKR1C3
Tchem
Family: Enzyme
Novelty: 0.00257785
Score: 0.967
Data Source: STRINGDB
HSD3B1
Tchem
Family: Enzyme
Novelty: 0.0019271
Score: 0.963
Data Source: STRINGDB
CYP19A1
Tclin
Family: Enzyme
Novelty: 0.0003187
Score: 0.959
Data Source: STRINGDB
HSD17B6
Tbio
Family: Enzyme
Novelty: 0.01428594
Score: 0.959
Data Source: STRINGDB
AKR1D1
Tbio
Family: Enzyme
Novelty: 0.01264297
Score: 0.959
Data Source: STRINGDB
AKR1C2
Tchem
Family: Enzyme
Novelty: 0.00134228
Score: 0.959
Data Source: STRINGDB
Publication Statistics
PubMed Score  352.70

PubMed score by year
PubTator Score  271.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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