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Tbio
MAPK4
Mitogen-activated protein kinase 4

Protein Summary
Description
Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity). Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus and phosphorylate nuclear targets. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000400384
  • ENSP00000383234
  • ENSG00000141639

Symbol
  • ERK4
  • PRKM4
  • ERK4
  • ERK-4
  • PRKM4
  • p63MAPK
  • p63-MAPK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
phenotype
0.86
protein domain
0.85
kinase perturbation
0.71
pathway
0.66


Related Tools
Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.85   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 354   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.85   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 354   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
2
3
85.5
myeloid white cell count
2
2
2
85.2
monocyte count
1
1
1
70.1
leukocyte count
1
1
1
43.8
diastolic blood pressure
1
1
1
30.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
85.5
myeloid white cell count
2
85.2
monocyte count
1
70.1
leukocyte count
1
43.8
diastolic blood pressure
1
30.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase 4
VGNC:7320
468536
Macaque
mitogen-activated protein kinase 4
700969
Mouse
MGI:2444559
225724
Rat
RGD:3047
54268
Dog
mitogen-activated protein kinase 4
VGNC:42998
491690
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase 4
Macaque
mitogen-activated protein kinase 4
Mouse
Rat
Dog
mitogen-activated protein kinase 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P31152-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (19)
MAPK family signaling cascades (R-HSA-5683057)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
MAPK family signaling cascades
Reactome
MAPK6/MAPK4 signaling
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
MAPK family signaling cascades
MAPK6/MAPK4 signaling
Signal Transduction
Gene Ontology Terms (15)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (83)
1 – 10 of 83
MAPK6
Tbio
Family: Kinase
Novelty: 0.01012514
p_int: 0.999999998
p_wrong: 2e-9
Score: 0.903
Data Source: BioPlex,STRINGDB
MAPKAPK5
Tchem
Family: Kinase
Novelty: 0.01349079
p_int: 0.999999428
p_ni: 5.69e-7
p_wrong: 4e-9
Score: 0.967
Data Source: BioPlex,Reactome,STRINGDB
RPS6KA4
Tchem
Family: Kinase
Novelty: 0.05213255
p_int: 0.999878617
p_ni: 0.000121189
p_wrong: 1.93e-7
Score: 0.352
Data Source: BioPlex,STRINGDB
DYRK2
Tchem
Family: Kinase
Novelty: 0.01724243
p_int: 0.999806995
p_ni: 0.000190728
p_wrong: 0.000002277
Data Source: BioPlex
INPPL1
Tchem
Family: Enzyme
Novelty: 0.00634126
p_int: 0.999625876
p_ni: 0.000374124
Data Source: BioPlex
AHCYL2
Tbio
Family: Enzyme
Novelty: 0.08695339
p_int: 0.988476537
p_ni: 0.011523463
Data Source: BioPlex
FASTKD5
Tdark
Family: Enzyme
Novelty: 0.67574493
p_int: 0.978759627
p_ni: 0.021240373
Score: 0.29
Data Source: BioPlex,STRINGDB
PLEKHH3
Tdark
Novelty: 2.43915121
p_int: 0.97500397
p_ni: 0.02499603
Data Source: BioPlex
PAK1
Tchem
Family: Kinase
Novelty: 0.00411227
p_int: 0.967832466
p_ni: 0.032166234
p_wrong: 0.000001301
Score: 0.92
Data Source: BioPlex,Reactome,STRINGDB
ANAPC5
Tbio
Family: Enzyme
Novelty: 0.02102572
p_int: 0.938432791
p_ni: 0.061567167
p_wrong: 4.2e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  39.85

PubMed score by year
PubTator Score  16.63

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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