Tbio S100A7 Protein S100-A7

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Protein S100-a7

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Protein S100-a7

DTO Classes

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Protein S100-a7

Protein Summary

Description

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. The protein is overexpressed in hyperproliferative skin diseases, exhibits antimicrobial activities against bacteria and induces immunomodulatory activities. [provided by RefSeq, Nov 2014]

Uniprot Accession IDs

• P31151
• Q5SY67
• Q6FGE3
• Q9H1E2

Gene Name

• S100A7

Ensembl ID

• ENST00000368722
• ENSP00000357711
• ENSG00000143556
• ENST00000368723
• ENSP00000357712

Symbol

• PSOR1
• S100A7C
• PSOR1
• S100A7c

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.91
protein complex	0.79
gene perturbation	0.76
biological process	0.75
protein domain	0.73

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 282.35   (req: < 5)

Gene RIFs: 97   (req: <= 3)

Antibodies: 502   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 282.35   (req: >= 5)

Gene RIFs: 97   (req: > 3)

Antibodies: 502   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (8)

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1 – 5 of 8

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neutrophil percentage of leukocytes	EFO_0007990	1	1	1		38.2
monocyte percentage of leukocytes	EFO_0007989	2	1	2		34.8
monocyte count	EFO_0005091	1	1	1		28
basophil percentage of leukocytes	EFO_0007992	1	1	1		17
matrix metalloproteinase 8 measurement	EFO_0008466	1	1	1		14.2

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 8

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neutrophil percentage of leukocytes	EFO_0007990	1		38.2
monocyte percentage of leukocytes	EFO_0007989	2		34.8
monocyte count	EFO_0005091	1		28
basophil percentage of leukocytes	EFO_0007992	1		17
matrix metalloproteinase 8 measurement	EFO_0008466	1		14.2

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Protein Structure (7 Structures, 1 AlphaFold Model)

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Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P31151-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (7)

Reactome (5)

KEGG (1)

PathwayCommons (1)

Antimicrobial peptides (R-HSA-6803157)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Antimicrobial peptides	89 targets	R-HSA-6803157
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Innate Immune System	1188 targets	R-HSA-168249
Reactome	Metal sequestration by antimicrobial proteins	6 targets	R-HSA-6799990
Reactome	Neutrophil degranulation	543 targets	R-HSA-6798695

Name	Explore in Pharos	Explore in Source
Antimicrobial peptides	89 targets	R-HSA-6803157
Immune System	2246 targets	R-HSA-168256
Innate Immune System	1188 targets	R-HSA-168249
Metal sequestration by antimicrobial proteins	6 targets	R-HSA-6799990
Neutrophil degranulation	543 targets	R-HSA-6798695

Gene Ontology Terms (27)

Functions (3)

Components (9)

Processes (15)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
calcium ion binding	Inferred from Direct Assay (IDA)	UniProtKB
RAGE receptor binding	Inferred from Physical Interaction (IPI)	UniProtKB
zinc ion binding	Non-traceable Author Statement (NAS)	UniProtKB

Protein-Protein Interactions (189)

Explore Interacting Targets

1 – 10 of 189

• See Interactions on String-DB

ZIC1

Tbio

Family:  TF

Novelty:  0.00491601

p_int:  0.99972651

p_ni:  0.00027349

Data Source:  BioPlex

TBC1D22B

Tbio

Novelty:  0.49852962

p_int:  0.996367372

p_ni:  0.003632628

Data Source:  BioPlex

PDE4DIP

Tbio

Novelty:  0.03414104

p_int:  0.996201365

p_ni:  0.003798635

Data Source:  BioPlex

MRPL38

Tdark

Novelty:  0.71587283

p_int:  0.994669131

p_ni:  0.005330869

Data Source:  BioPlex

SYS1

Tbio

Novelty:  0.03311919

p_int:  0.986586407

p_ni:  0.013413593

Data Source:  BioPlex

KLHL11

Tbio

Novelty:  0.1537041

p_int:  0.98599727

p_ni:  0.01400273

Data Source:  BioPlex

SINHCAF

Tdark

Novelty:  0.18692832

p_int:  0.979148645

p_ni:  0.020851355

Data Source:  BioPlex

ZNF354C

Tdark

Family:  TF

Novelty:  0.09978239

p_int:  0.973463112

p_ni:  0.026536888

Score:  0.186

Data Source:  BioPlex,STRINGDB

RNF25

Tbio

Family:  Enzyme

Novelty:  0.08945219

p_int:  0.959224807

p_ni:  0.040775193

Score:  0.186

Data Source:  BioPlex,STRINGDB

CDK15

Tchem

Family:  Kinase

Novelty:  0.3870338

p_int:  0.950778877

p_ni:  0.049221123

Data Source:  BioPlex

Publication Statistics

PubMed Score  282.35

PubMed score by year

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PubTator Score  130.75

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Calcium
Complete proteome
Cytoplasm
Direct protein sequencing
Disulfide bond
Metal-binding
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
basophil percentage of leukocytes
granulocyte percentage of myeloid white cells
high density lipoprotein cholesterol measurement
matrix metalloproteinase 8 measurement
monocyte count
monocyte percentage of leukocytes
neutrophil percentage of leukocytes
sleep duration