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Tbio
S100A7
Protein S100-A7

Protein Summary
Description
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. The protein is overexpressed in hyperproliferative skin diseases, exhibits antimicrobial activities against bacteria and induces immunomodulatory activities. [provided by RefSeq, Nov 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368722
  • ENSP00000357711
  • ENSG00000143556
  • ENST00000368723
  • ENSP00000357712

Symbol
  • PSOR1
  • S100A7C
  • PSOR1
  • S100A7c
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.91
protein complex
0.79
gene perturbation
0.76
biological process
0.75
protein domain
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 282.35   (req: < 5)
Gene RIFs: 97   (req: <= 3)
Antibodies: 502   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 282.35   (req: >= 5)
Gene RIFs: 97   (req: > 3)
Antibodies: 502   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
1
1
1
38.2
monocyte percentage of leukocytes
2
1
2
34.8
monocyte count
1
1
1
28
basophil percentage of leukocytes
1
1
1
17
matrix metalloproteinase 8 measurement
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
1
38.2
monocyte percentage of leukocytes
2
34.8
monocyte count
1
28
basophil percentage of leukocytes
1
17
matrix metalloproteinase 8 measurement
1
14.2
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P31151-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metal sequestration by antimicrobial proteins
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Immune System
Innate Immune System
Metal sequestration by antimicrobial proteins
Neutrophil degranulation
Gene Ontology Terms (27)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (189)
1 – 10 of 189
ZIC1
Tbio
Family:  TF
Novelty:  0.00491601
p_int:  0.99972651
p_ni:  0.00027349
Data Source:  BioPlex
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.996367372
p_ni:  0.003632628
Data Source:  BioPlex
PDE4DIP
Tbio
Novelty:  0.03414104
p_int:  0.996201365
p_ni:  0.003798635
Data Source:  BioPlex
MRPL38
Tdark
Novelty:  0.71587283
p_int:  0.994669131
p_ni:  0.005330869
Data Source:  BioPlex
SYS1
Tbio
Novelty:  0.03311919
p_int:  0.986586407
p_ni:  0.013413593
Data Source:  BioPlex
KLHL11
Tbio
Novelty:  0.1537041
p_int:  0.98599727
p_ni:  0.01400273
Data Source:  BioPlex
SINHCAF
Tdark
Novelty:  0.18692832
p_int:  0.979148645
p_ni:  0.020851355
Data Source:  BioPlex
ZNF354C
Tdark
Family:  TF
Novelty:  0.09978239
p_int:  0.973463112
p_ni:  0.026536888
Score:  0.186
Data Source:  BioPlex,STRINGDB
RNF25
Tbio
Family:  Enzyme
Novelty:  0.08945219
p_int:  0.959224807
p_ni:  0.040775193
Score:  0.186
Data Source:  BioPlex,STRINGDB
CDK15
Tchem
Family:  Kinase
Novelty:  0.3870338
p_int:  0.950778877
p_ni:  0.049221123
Data Source:  BioPlex
Publication Statistics
PubMed Score  282.35

PubMed score by year
PubTator Score  130.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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