Protein Summary
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. The protein is overexpressed in hyperproliferative skin diseases, exhibits antimicrobial activities against bacteria and induces immunomodulatory activities. [provided by RefSeq, Nov 2014]
- ENST00000368722
- ENSP00000357711
- ENSG00000143556
- ENST00000368723
- ENSP00000357712
- PSOR1
- S100A7C
- PSOR1
- S100A7c
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 0.91 | ||
protein complex | 0.79 | ||
gene perturbation | 0.76 | ||
biological process | 0.75 | ||
protein domain | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 282.35 (req: < 5)
Gene RIFs: 97 (req: <= 3)
Antibodies: 502 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 282.35 (req: >= 5)
Gene RIFs: 97 (req: > 3)
Antibodies: 502 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (189)
ZNF354C
Family: TF
Novelty: 0.09978239
p_int: 0.973463112
p_ni: 0.026536888
Score: 0.186
Data Source: BioPlex,STRINGDB
RNF25
Family: Enzyme
Novelty: 0.08945219
p_int: 0.959224807
p_ni: 0.040775193
Score: 0.186
Data Source: BioPlex,STRINGDB
CDK15
Family: Kinase
Novelty: 0.3870338
p_int: 0.950778877
p_ni: 0.049221123
Data Source: BioPlex
Nearest Tclin Targets
Pathways (7)
Reactome (5)
KEGG (1)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Antimicrobial peptides | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Metal sequestration by antimicrobial proteins | ||||
Reactome | Neutrophil degranulation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Antimicrobial peptides | ||||
Immune System | ||||
Innate Immune System | ||||
Metal sequestration by antimicrobial proteins | ||||
Neutrophil degranulation | ||||
Viral Interactions (0)
Gene Ontology Terms (27)
Functions (3)
Components (9)
Processes (15)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
neutrophil percentage of leukocytes | 1 | 1 | 1 | 38.2 | |||||
monocyte percentage of leukocytes | 2 | 1 | 2 | 34.8 | |||||
monocyte count | 1 | 1 | 1 | 28 | |||||
basophil percentage of leukocytes | 1 | 1 | 1 | 17 | |||||
matrix metalloproteinase 8 measurement | 1 | 1 | 1 | 14.2 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
neutrophil percentage of leukocytes | 1 | 38.2 | |||||
monocyte percentage of leukocytes | 2 | 34.8 | |||||
monocyte count | 1 | 28 | |||||
basophil percentage of leukocytes | 1 | 17 | |||||
matrix metalloproteinase 8 measurement | 1 | 14.2 | |||||
Find similar targets by:
IDG Resources
Orthologs
Publication Statistics
PubMed Score 282.35
PubMed score by year
PubTator Score 130.75
PubTator score by year
Related Publications
Text Mined References (132)
GeneRif Annotations (97)
Items per page:
0 of 0
PMID | Year | Title |
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