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Tbio
SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Protein Summary
Description
Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (PubMed:24781757). Can act as a tumor suppressor (PubMed:20484225). This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264932
  • ENSP00000264932
  • ENSG00000073578
  • ENST00000510361
  • ENSP00000427703

Symbol
  • SDH2
  • SDHF
  • FP
  • PGL5
  • SDH1
  • SDH2
  • SDHF
  • CMD1GG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
1
co-expressed gene
0.99
disease perturbation
0.95
transcription factor perturbation
0.91


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 376.47   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 331   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 376.47   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 331   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (18)
1 – 5 of 18
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
succinate dehydrogenase complex flavoprotein subunit A
VGNC:7150
107974583
Macaque
succinate dehydrogenase complex flavoprotein subunit A
708018
Mouse
MGI:1914195
66945
Rat
RGD:621557
157074
Dog
succinate dehydrogenase complex flavoprotein subunit A
VGNC:45949
478634
Species
Name
OMA
EggNOG
Inparanoid
Chimp
succinate dehydrogenase complex flavoprotein subunit A
Macaque
succinate dehydrogenase complex flavoprotein subunit A
Mouse
Rat
Dog
succinate dehydrogenase complex flavoprotein subunit A
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P31040-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (28)
Citric acid cycle (TCA cycle) (R-HSA-71403)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Citric acid cycle (TCA cycle)
Reactome
Metabolism
Reactome
Pyruvate metabolism and Citric Acid (TCA) cycle
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Name
Explore in Pharos
Explore in Source
Citric acid cycle (TCA cycle)
Metabolism
Pyruvate metabolism and Citric Acid (TCA) cycle
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Gene Ontology Terms (17)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (338)
1 – 10 of 338
SDHAF4
Tbio
Family: Enzyme
Novelty: 0.24150488
p_int: 1
Score: 0.975
Data Source: BioPlex,STRINGDB
SDHAF2
Tbio
Family: Enzyme
Novelty: 0.00495668
p_int: 0.999999954
p_wrong: 4.5e-8
Score: 0.986
Data Source: BioPlex,STRINGDB
PDZRN3
Tbio
Family: Enzyme
Novelty: 0.06663842
p_int: 0.999999493
p_ni: 5.05e-7
p_wrong: 1e-9
Score: 0.187
Data Source: BioPlex,STRINGDB
PDSS2
Tbio
Family: Enzyme
Novelty: 0.02716477
p_int: 0.999995493
p_ni: 0.000004503
p_wrong: 5e-9
Score: 0.839
Data Source: BioPlex,STRINGDB
PDSS1
Tbio
Family: Enzyme
Novelty: 0.01542427
p_int: 0.99989696
p_ni: 0.000043607
p_wrong: 0.000059433
Score: 0.772
Data Source: BioPlex,STRINGDB
PDP1
Tbio
Family: Enzyme
Novelty: 0.00442352
p_int: 0.999813995
p_ni: 0.000186005
Score: 0.297
Data Source: BioPlex,STRINGDB
SDHAF3
Tbio
Family: Enzyme
Novelty: 0.01155522
p_int: 0.998216176
p_ni: 0.001783824
Score: 0.94
Data Source: BioPlex,STRINGDB
SIRT3
Tchem
Family: Epigenetic
Novelty: 0.00101187
p_int: 0.991376781
p_ni: 0.008623219
Score: 0.813
Data Source: BioPlex,STRINGDB
CHCHD4
Tbio
Novelty: 0.01204944
p_int: 0.972404725
p_ni: 0.027595275
Score: 0.159
Data Source: BioPlex,STRINGDB
ACAD9
Tbio
Family: Enzyme
Novelty: 0.03238308
p_int: 0.93547799
p_ni: 0.06452201
Score: 0.627
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  376.47

PubMed score by year
PubTator Score  118.41

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer