Tbio SDHA Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Protein Summary

Description

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (PubMed:24781757). Can act as a tumor suppressor (PubMed:20484225). This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

Uniprot Accession IDs

• P31040
• A8K5J6
• B4DJ60
• E9PBJ5
• Q16395
• Q59GW8
• Q8IW48
• Q9UMY5

Gene Name

• SDHA

Ensembl ID

• ENST00000264932
• ENSP00000264932
• ENSG00000073578
• ENST00000510361
• ENSP00000427703

Symbol

• SDH2
• SDHF
• FP
• PGL5
• SDH1
• SDH2
• SDHF
• CMD1GG

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
kinase perturbation	1
co-expressed gene	0.99
disease perturbation	0.95
transcription factor perturbation	0.91

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Oxidase / Succinate Dehydrogenase [Ubiquinone] Flavoprotein Subunit, Mitochondrial

Protein / Oxidoreductase / Dehydrogenase / Succinate Dehydrogenase [Ubiquinone] Flavoprotein Subunit, Mitochondrial

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / Succinate Dehydrogenase [Ubiquinone] Flavoprotein Subunit, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 499.44   (req: < 5)

Gene RIFs: 63   (req: <= 3)

Antibodies: 331   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 499.44   (req: >= 5)

Gene RIFs: 63   (req: > 3)

Antibodies: 331   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0