You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NTS
Neurotensin/neuromedin N

Protein Summary
Description
Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle. This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. Neurotensin is a secreted tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the maintenance of gut structure and function, and in the regulation of fat metabolism. Neurotensin also exhibits antimicrobial activity against bacteria and fungi. Tissue-specific processing may lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may represent more stable peptides that are also biologically active. [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256010
  • ENSP00000256010
  • ENSG00000133636

Symbol
  • NN
  • NT
  • NT/N
  • NTS1
  • NMN-125
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.68
gene perturbation
0.68
chemical
0.64
disease
0.64
small molecule perturbation
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3059.41   (req: < 5)
Gene RIFs: 67   (req: <= 3)
Antibodies: 282   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3059.41   (req: >= 5)
Gene RIFs: 67   (req: > 3)
Antibodies: 282   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
1
1
8.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
8.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neurotensin
VGNC:5511
745818
Macaque
neurotensin
700189
Mouse
MGI:1328351
67405
Rat
RGD:621612
299757
Dog
neurotensin
VGNC:44013
611687
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neurotensin
Macaque
neurotensin
Mouse
Rat
Dog
neurotensin
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P30990-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (317)
1 – 10 of 317
NTSR1
Tchem
Family: GPCR
Novelty: 0.00067612
Score: 0.999
Data Source: Reactome,STRINGDB
NTSR2
Tchem
Family: GPCR
Novelty: 0.00699381
Score: 0.998
Data Source: Reactome,STRINGDB
TAC1
Tbio
Novelty: 0.00006575
Score: 0.988
Data Source: STRINGDB
CCK
Tbio
Novelty: 0.00012268
Score: 0.985
Data Source: STRINGDB
NPS
Tbio
Novelty: 0.00692108
Score: 0.984
Data Source: STRINGDB
GRP
Tbio
Novelty: 0.00034247
Score: 0.983
Data Source: STRINGDB
GAST
Tbio
Novelty: 0.00011795
Score: 0.977
Data Source: STRINGDB
NLN
Tbio
Family: Enzyme
Novelty: 0.01217367
Score: 0.975
Data Source: Reactome,STRINGDB
MLN
Tbio
Novelty: 0.0010297
Score: 0.972
Data Source: STRINGDB
KNG1
Tchem
Novelty: 0.00007684
Score: 0.971
Data Source: STRINGDB
Publication Statistics
PubMed Score  3059.41

PubMed score by year
PubTator Score  912.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: