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Tbio
NTS
Neurotensin/neuromedin N

Protein Summary
Description
Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle. This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. Neurotensin is a secreted tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the maintenance of gut structure and function, and in the regulation of fat metabolism. Neurotensin also exhibits antimicrobial activity against bacteria and fungi. Tissue-specific processing may lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may represent more stable peptides that are also biologically active. [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256010
  • ENSP00000256010
  • ENSG00000133636

Symbol
  • NN
  • NT
  • NT/N
  • NTS1
  • NMN-125
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.68
gene perturbation
0.68
chemical
0.64
disease
0.64
small molecule perturbation
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3081.08   (req: < 5)
Gene RIFs: 67   (req: <= 3)
Antibodies: 282   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3081.08   (req: >= 5)
Gene RIFs: 67   (req: > 3)
Antibodies: 282   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Protein-Protein Interactions (317)
1 – 10 of 317
NTSR1
Tchem
Family:  GPCR
Novelty:  0.00067612
Score:  0.999
Data Source:  Reactome,STRINGDB
NTSR2
Tchem
Family:  GPCR
Novelty:  0.00699381
Score:  0.998
Data Source:  Reactome,STRINGDB
TAC1
Tbio
Novelty:  0.00006575
Score:  0.988
Data Source:  STRINGDB
CCK
Tbio
Novelty:  0.00012268
Score:  0.985
Data Source:  STRINGDB
NPS
Tbio
Novelty:  0.00692108
Score:  0.984
Data Source:  STRINGDB
GRP
Tbio
Novelty:  0.00034247
Score:  0.983
Data Source:  STRINGDB
GAST
Tbio
Novelty:  0.00011795
Score:  0.977
Data Source:  STRINGDB
NLN
Tbio
Family:  Enzyme
Novelty:  0.01217367
Score:  0.975
Data Source:  Reactome,STRINGDB
MLN
Tbio
Novelty:  0.0010297
Score:  0.972
Data Source:  STRINGDB
KNG1
Tbio
Novelty:  0.00007684
Score:  0.971
Data Source:  STRINGDB
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
1
1
2.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
2.7
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neurotensin
VGNC:5511
745818
Macaque
neurotensin
700189
Mouse
MGI:1328351
67405
Rat
RGD:621612
299757
Dog
neurotensin
VGNC:44013
611687
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neurotensin
Macaque
neurotensin
Mouse
Rat
Dog
neurotensin
Publication Statistics
PubMed Score 3081.08
PubMed score by year
PubTator Score 912.77
PubTator score by year