NTSR1
Neurotensin receptor type 1
Protein Summary
G-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:8381365, PubMed:21725197, PubMed:23140271). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (PubMed:21725197). Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion. [provided by RefSeq, Jul 2008]
- ENST00000370501
- ENSP00000359532
- ENSG00000101188
- NTRR
- NTR
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.8 | ||
ligand (chemical) | 0.66 | ||
cell type or tissue | 0.65 | ||
small molecule perturbation | 0.63 | ||
disease | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1984.07 (req: < 5)
Gene RIFs: 78 (req: <= 3)
Antibodies: 296 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1984.07 (req: >= 5)
Gene RIFs: 78 (req: > 3)
Antibodies: 296 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 32
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 115
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0