You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
CALCR
Calcitonin receptor

Protein Summary
Description
This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000415529
  • ENSP00000413179
  • ENSG00000004948
  • ENST00000423724
  • ENSP00000391369

Symbol
  • CRT
  • CTR
  • CT-R
  • CTR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein)
0.95
gene perturbation
0.9
protein domain
0.85
cell type or tissue
0.83
disease
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 822.98   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 822.98   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
7
3
7
95.1
birth weight
1
1
1
60.3
appendicular lean mass
1
1
1
57.7
2
2
1
1
57.5
triglyceride measurement
1
1
2
50.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
7
95.1
birth weight
1
60.3
appendicular lean mass
1
57.7
1
1
57.5
triglyceride measurement
2
50.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcitonin receptor
VGNC:4290
472445
Macaque
calcitonin receptor
701093
Mouse
MGI:101950
12311
Rat
RGD:621001
116506
Dog
calcitonin receptor
VGNC:38664
482306
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcitonin receptor
Macaque
calcitonin receptor
Mouse
Rat
Dog
calcitonin receptor
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P30988-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Calcitonin-like ligand receptors (R-HSA-419812)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Calcitonin-like ligand receptors
Reactome
Class B/2 (Secretin family receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Calcitonin-like ligand receptors
Class B/2 (Secretin family receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Protein-Protein Interactions (174)
1 – 10 of 174
RAMP1
Tclin
Novelty: 0.00831253
Score: 0.99
Data Source: Reactome,STRINGDB
CALCA
Tbio
Novelty: 0.00010496
Score: 0.987
Data Source: Reactome,STRINGDB
CALCA
Tclin
Novelty: 0.00010496
Score: 0.987
Data Source: STRINGDB
RAMP3
Tclin
Novelty: 0.01616194
Score: 0.984
Data Source: Reactome,STRINGDB
GNB1
Tbio
Novelty: 0.02477955
Score: 0.982
Data Source: STRINGDB
GNG2
Tbio
Novelty: 0.04807242
Score: 0.981
Data Source: STRINGDB
RAMP2
Tclin
Novelty: 0.01086538
Score: 0.975
Data Source: Reactome,STRINGDB
IAPP
Tbio
Novelty: 0.0005195
Score: 0.975
Data Source: Reactome,STRINGDB
CALCB
Tclin
Novelty: 0.02069808
Score: 0.97
Data Source: STRINGDB
ADM
Tbio
Novelty: 0.0004958
Score: 0.965
Data Source: STRINGDB
Publication Statistics
PubMed Score  822.98

PubMed score by year
PubTator Score  729.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: