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Tclin
HTR1F
5-hydroxytryptamine receptor 1F

Protein Summary
Description
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319595
  • ENSP00000322924
  • ENSG00000179097

Symbol
  • HTR1EL
  • 5HT6
  • MR77
  • 5-HT1F
  • HTR1EL
  • 5-HT-1F
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.97
microRNA
0.65
molecular function
0.63
drug
0.6
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 135.1   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 197   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 135.1   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 111
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 14