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Tclin
HTR1F
5-hydroxytryptamine receptor 1F

Protein Summary
Description
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319595
  • ENSP00000322924
  • ENSG00000179097

Symbol
  • HTR1EL
  • 5HT6
  • MR77
  • 5-HT1F
  • HTR1EL
  • 5-HT-1F
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.97
microRNA
0.65
molecular function
0.63
drug
0.6
protein domain
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.52   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 197   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.52   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 105
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 14
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
3.1
mean corpuscular volume
1
1
1
1.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
3.1
mean corpuscular volume
1
1.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
5-hydroxytryptamine receptor 1F
VGNC:53371
470863
Macaque
5-hydroxytryptamine receptor 1F
693418
Mouse
MGI:99842
15557
Rat
RGD:71083
60448
Dog
5-hydroxytryptamine receptor 1F
VGNC:41826
100683938
Species
Name
OMA
EggNOG
Inparanoid
Chimp
5-hydroxytryptamine receptor 1F
Macaque
5-hydroxytryptamine receptor 1F
Mouse
Rat
Dog
5-hydroxytryptamine receptor 1F
Pathways (17)
Amine ligand-binding receptors (R-HSA-375280)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Protein-Protein Interactions (239)
1 – 10 of 239
GNAI2
Tbio
Novelty: 0.03014729
Score: 0.924
Data Source: STRINGDB
GRM7
Tchem
Family: GPCR
Novelty: 0.00416377
Score: 0.924
Data Source: STRINGDB
GNG2
Tbio
Novelty: 0.04807242
Score: 0.924
Data Source: STRINGDB
GNG7
Tbio
Novelty: 0.08478455
Score: 0.922
Data Source: STRINGDB
GRM4
Tchem
Family: GPCR
Novelty: 0.00380434
Score: 0.921
Data Source: STRINGDB
LPAR5
Tchem
Family: GPCR
Novelty: 0.01883439
Score: 0.919
Data Source: STRINGDB
GRM8
Tchem
Family: GPCR
Novelty: 0.00827879
Score: 0.916
Data Source: STRINGDB
GNB5
Tbio
Novelty: 0.0067714
Score: 0.916
Data Source: STRINGDB
GRM2
Tchem
Family: GPCR
Novelty: 0.00132156
Score: 0.916
Data Source: STRINGDB
GABBR1
Tclin
Family: GPCR
Novelty: 0.00086493
Score: 0.916
Data Source: STRINGDB
Publication Statistics
PubMed Score  96.52

PubMed score by year
PubTator Score  22.26

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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