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Tclin
CHRNB4
Neuronal acetylcholine receptor subunit beta-4

Protein Classes
Protein Summary
Description
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is found within a conserved gene cluster and encodes one of the beta subunits of the nicotinic acetylcholine receptor (nAChRs) superfamily which form ligand-gated ion channels with a central pore that forms a cation channel. Neuronal nAChRs are pentameric structures that can be either homomeric or heteromeric, with heteromeric structures containing both alpha and beta subunits. Each subunit contains an extracellular amino terminus and four transmembrane domains. Nicotine is one of the agonists that binds to the receptor. Variants in this gene have been associated with nicotine dependence and lung cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261751
  • ENSP00000261751
  • ENSG00000117971
  • ENST00000412074
  • ENSP00000416386
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
molecular function
0.84
chemical
0.77
gene perturbation
0.75
biological term
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.09   (req: < 5)
Gene RIFs: 76   (req: <= 3)
Antibodies: 160   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.09   (req: >= 5)
Gene RIFs: 76   (req: > 3)
Antibodies: 160   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.2
73.1
1
1
0
1.1
69.6
smoking status measurement
1
1
0
1.2
68.6
1
1
0
1.2
65.8
1
1
0
1.2
58
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
73.1
0
1.1
69.6
smoking status measurement
0
1.2
68.6
0
1.2
65.8
0
1.2
58
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cholinergic receptor nicotinic beta 4 subunit
VGNC:7415
453570
Macaque
cholinergic receptor nicotinic beta 4 subunit
716649
Mouse
MGI:87892
108015
Rat
RGD:2351
25103
Dog
cholinergic receptor nicotinic beta 4 subunit
VGNC:39245
482110
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cholinergic receptor nicotinic beta 4 subunit
Macaque
cholinergic receptor nicotinic beta 4 subunit
Mouse
Rat
Dog
cholinergic receptor nicotinic beta 4 subunit
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P30926-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (75)
Acetylcholine binding and downstream events (R-HSA-181431)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acetylcholine binding and downstream events
Reactome
Highly calcium permeable nicotinic acetylcholine receptors
Reactome
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Reactome
Highly sodium permeable acetylcholine nicotinic receptors
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Acetylcholine binding and downstream events
Highly calcium permeable nicotinic acetylcholine receptors
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Highly sodium permeable acetylcholine nicotinic receptors
Immune System
Gene Ontology Terms (35)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
DFLAT
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (230)
1 – 10 of 230
UBA52
Tbio
Novelty: 0.01637744
p_int: 0.999999992
p_ni: 6e-9
p_wrong: 2e-9
Data Source: BioPlex
GABRB3
Tclin
Family: IC
Novelty: 0.00485997
p_int: 0.999871347
p_ni: 0.000121053
p_wrong: 0.0000076
Data Source: BioPlex
ICAM4
Tbio
Novelty: 0.0269875
p_int: 0.999843933
p_ni: 0.000155872
p_wrong: 1.95e-7
Data Source: BioPlex
GLT8D2
Tbio
Family: Enzyme
Novelty: 0.79488367
p_int: 0.999564623
p_ni: 0.00043236
p_wrong: 0.000003017
Data Source: BioPlex
TAPBP
Tbio
Novelty: 0.00328098
p_int: 0.999501968
p_ni: 0.000222773
p_wrong: 0.000275259
Data Source: BioPlex
PIGB
Tbio
Family: Enzyme
Novelty: 0.05237713
p_int: 0.999501968
p_ni: 0.000222773
p_wrong: 0.000275259
Data Source: BioPlex
ATP13A3
Tbio
Family: Transporter
Novelty: 0.13498113
p_int: 0.99906835
p_ni: 0.00093165
Score: 0.281
Data Source: BioPlex,STRINGDB
UGT3A2
Tbio
Family: Enzyme
Novelty: 0.35904542
p_int: 0.99894042
p_ni: 0.000431468
p_wrong: 0.000628113
Data Source: BioPlex
MIB2
Tbio
Family: Enzyme
Novelty: 0.044378
p_int: 0.998788785
p_ni: 0.001205532
p_wrong: 0.000005683
Data Source: BioPlex
RHBDD3
Tbio
Novelty: 0.04564748
p_int: 0.997287656
p_ni: 0.002712201
p_wrong: 1.43e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  71.09

PubMed score by year
PubTator Score  36.06

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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