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Tbio
POLR2B
DNA-directed RNA polymerase II subunit RPB2

Protein Summary
Description
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity). This gene encodes the second largest subunit of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase that catalyzes the transcription of DNA into precursors of mRNA, snRNA and microRNA. This subunit and the largest subunit form opposite sides of the cent ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314595
  • ENSP00000312735
  • ENSG00000047315
  • ENST00000381227
  • ENSP00000370625

Symbol
  • RPB2
  • POL2RB
  • hRPB140
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
disease perturbation
0.93
hub protein
0.88
virus perturbation
0.85
molecular function
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 943.62   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 943.62   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (788)
LMO2
Tbio
Novelty:  0.0038279
p_int:  0.996488194
p_ni:  0.003511806
Score:  0.534
Data Source:  BioPlex,STRINGDB
POLR2G
Tbio
Family:  Enzyme
Novelty:  0.01235379
p_int:  0.991469254
p_ni:  0.008530746
Score:  0.999
Data Source:  BioPlex,STRINGDB
POLR2J
Tbio
Family:  Enzyme
Novelty:  0.02344868
p_int:  0.98965177
p_ni:  0.01034823
Score:  0.999
Data Source:  BioPlex,STRINGDB
Q6EEV4
Tbio
Family:  Enzyme
Novelty:  0.11413088
p_int:  0.982846876
p_ni:  0.017153124
Score:  0.861
Data Source:  BioPlex,STRINGDB
RPRD1B
Tbio
Novelty:  0.0444394
p_int:  0.955827532
p_ni:  0.044172468
Score:  0.989
Data Source:  BioPlex,STRINGDB
POLR2D
Tdark
Family:  Enzyme
Novelty:  0.11021614
p_int:  0.924269316
p_ni:  0.075730684
Score:  0.999
Data Source:  BioPlex,STRINGDB
GPN3
Tbio
Family:  Enzyme
Novelty:  0.13817794
p_int:  0.889048525
p_ni:  0.110951475
Score:  0.805
Data Source:  BioPlex,STRINGDB
PIH1D1
Tbio
Novelty:  0.10737369
p_int:  0.83503011
p_ni:  0.16496989
Score:  0.787
Data Source:  BioPlex,STRINGDB
GPN2
Tdark
Family:  Enzyme
Novelty:  0.26461894
p_int:  0.799832419
p_ni:  0.200167581
Score:  0.882
Data Source:  BioPlex,STRINGDB
ASB6
Tdark
Novelty:  0.32074223
p_int:  0.796290703
p_ni:  0.203709297
Score:  0.711
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (74)
Abortive elongation of HIV-1 transcript in the absence of Tat (R-HSA-167242)

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Find Similar Targets
Items per page:
1 – 5 of 70
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Abortive elongation of HIV-1 transcript in the absence of Tat
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
DNA Repair
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Abortive elongation of HIV-1 transcript in the absence of Tat
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
DNA Repair
Developmental Biology
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
4
3
5
91.1
5
5
3
1.1
83.5
lymphocyte count
2
2
2
76.4
platelet count
3
2
3
75.6
mean reticulocyte volume
1
1
1
75.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
5
91.1
3
1.1
83.5
lymphocyte count
2
76.4
platelet count
3
75.6
mean reticulocyte volume
1
75.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase II subunit B
VGNC:8668
461305
Macaque
RNA polymerase II subunit B
694664
Mouse
MGI:2388280
231329
Rat
RGD:1309477
289561
Dog
RNA polymerase II subunit B
VGNC:44793
475152
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase II subunit B
Macaque
RNA polymerase II subunit B
Mouse
Rat
Dog
RNA polymerase II subunit B
Publication Statistics
PubMed Score 943.62
PubMed score by year
PubTator Score 208.07
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title