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Tclin
SSTR2
Somatostatin receptor type 2

Protein Summary
Description
Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization. Somatostatin acts at many sites to inhibit the release of many hormones and other secretory protein ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
1
disease perturbation
0.79
biological term
0.77
biological process
0.68
virus perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 551.1   (req: < 5)
Gene RIFs: 132   (req: <= 3)
Antibodies: 348   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 551.1   (req: >= 5)
Gene RIFs: 132   (req: > 3)
Antibodies: 348   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 209
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
Pathways (42)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
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Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Protein-Protein Interactions (295)
1 – 10 of 295
SST
Tbio
Novelty: 0.0000732
Score: 0.997
Data Source: STRINGDB
CORT
Tbio
Novelty: 0.0034818
Score: 0.969
Data Source: STRINGDB
POMC
Tbio
Novelty: 0.00002654
Score: 0.957
Data Source: STRINGDB
GNAI1
Tbio
Novelty: 0.12575547
Score: 0.954
Data Source: STRINGDB
PPY
Tbio
Novelty: 0.00056678
Score: 0.94
Data Source: STRINGDB
SSTR3
Tclin
Family: GPCR
Novelty: 0.00379402
Score: 0.94
Data Source: STRINGDB
NPY
Tbio
Novelty: 0.00014761
Score: 0.94
Data Source: STRINGDB
GNAI2
Tbio
Novelty: 0.04542644
Score: 0.937
Data Source: STRINGDB
CNR1
Tclin
Family: GPCR
Novelty: 0.00017618
Score: 0.937
Data Source: STRINGDB
NPB
Tdark
Novelty: 0.00254878
Score: 0.936
Data Source: STRINGDB
Publication Statistics
PubMed Score  551.10

PubMed score by year
PubTator Score  434.73

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer