Tclin SSTR2 Somatostatin receptor type 2

Protein Summary

Description

Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization. Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P30874
• A8K3Y0
• B2R9P7
• Q4VBP0
• Q96GE0
• Q96TF2
• Q9BWH1
• SS-2-R

Gene Name

• SSTR2

Ensembl ID

• ENST00000357585
• ENSP00000350198
• ENSG00000180616

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (chemical)	1
disease perturbation	0.79
biological term	0.77
biological process	0.68
virus perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Somatostatin Receptor Type 2

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Somatostatin Receptor Type 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 692.28   (req: < 5)

Gene RIFs: 160   (req: <= 3)

Antibodies: 348   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 692.28   (req: >= 5)

Gene RIFs: 160   (req: > 3)

Antibodies: 348   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 327

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7