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Tclin
SSTR1
Somatostatin receptor type 1

Protein Summary
Description
Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins. Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. The protein encoded by this gene is a member of the superfamily of somatostatin receptors having seven transmembrane segments. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein c ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267377
  • ENSP00000267377
  • ENSG00000139874

Symbol
  • SS1R
  • SS1-R
  • SRIF-2
  • SS-1-R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.84
ligand (chemical)
0.8
cell type or tissue
0.61
PubMedID
0.6
biological process
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 152.1   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 400   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 152.1   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 400   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 67
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (278)
SST
Tbio
Novelty:  0.00005944
Score:  0.995
Data Source:  STRINGDB
CORT
Tbio
Novelty:  0.00789975
Score:  0.97
Data Source:  STRINGDB
POMC
Tbio
Novelty:  0.00002436
Score:  0.955
Data Source:  STRINGDB
NPB
Tdark
Novelty:  0.00936692
Score:  0.943
Data Source:  STRINGDB
NPY
Tbio
Novelty:  0.00012637
Score:  0.941
Data Source:  STRINGDB
PPY
Tbio
Novelty:  0.00060933
Score:  0.94
Data Source:  STRINGDB
SSTR5
Tclin
Family:  GPCR
Novelty:  0.00568309
Score:  0.94
Data Source:  STRINGDB
GNAI1
Tbio
Novelty:  0.0488971
Score:  0.939
Data Source:  STRINGDB
NPW
Tbio
Novelty:  0.03174263
Score:  0.936
Data Source:  STRINGDB
GAL
Tbio
Novelty:  0.0005132
Score:  0.935
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5-HIAA measurement
1
1
1
1.8
MHPG measurement
1
1
1
1.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5-HIAA measurement
1
1.8
MHPG measurement
1
1.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
somatostatin receptor 1
VGNC:12493
467434
Mouse
MGI:98327
20605
Rat
RGD:3762
25033
Dog
somatostatin receptor 1
VGNC:46843
403455
Horse
somatostatin receptor 1
VGNC:23620
100060276
Species
Name
OMA
EggNOG
Inparanoid
Chimp
somatostatin receptor 1
Mouse
Rat
Dog
somatostatin receptor 1
Horse
somatostatin receptor 1
Publication Statistics
PubMed Score 152.10
PubMed score by year
PubTator Score 143.87
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title