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Tchem
ALDH3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

Protein Summary
Description
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:1737758). Preferentially oxidizes aromatic aldehyde substrates (PubMed:1737758). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity). Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225740
  • ENSP00000225740
  • ENSG00000108602
  • ENST00000444455
  • ENSP00000388469
  • ENST00000457500
  • ENSP00000411821

Symbol
  • ALDH3
  • ALDH3
  • ALDHIII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
gene perturbation
0.85
small molecule perturbation
0.71
chemical
0.7
cell type or tissue
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.12   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 423   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.12   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 423   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 14
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (14)
1 – 10 of 14
CHEMBL3128208
chemical structure image
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CHEMBL1453099
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CHEMBL1328547
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CHEMBL3128209
chemical structure image
CHEMBL1492620
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CHEMBL3128204
chemical structure image
CHEMBL3112689
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CHEMBL1308268
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CHEMBL3112688
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GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
1
2
2
37.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
2
37.6
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aldehyde dehydrogenase 3 family member A1
VGNC:9122
468186
Macaque
aldehyde dehydrogenase 3 family member A1
703870
Mouse
MGI:1353451
11670
Rat
RGD:2088
25375
Dog
aldehyde dehydrogenase 3 family member A1
VGNC:37786
489526
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aldehyde dehydrogenase 3 family member A1
Macaque
aldehyde dehydrogenase 3 family member A1
Mouse
Rat
Dog
aldehyde dehydrogenase 3 family member A1
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (24)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Metabolism
Reactome
Phase I - Functionalization of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Metabolism
Phase I - Functionalization of compounds
Gene Ontology Terms (13)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CACAO
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (123)
1 – 10 of 123
IGHG3
Tdark
p_int: 0.99981331
p_ni: 0.000181141
p_wrong: 0.000005549
Data Source: BioPlex
ZNF446
Tdark
Family: TF
Novelty: 0.80369039
p_int: 0.99962118
p_ni: 0.000378806
p_wrong: 1.4e-8
Score: 0.179
Data Source: BioPlex,STRINGDB
ALDH3A2
Tbio
Family: Enzyme
Novelty: 0.0059198
p_int: 0.989585346
p_ni: 0.010414654
Score: 0.216
Data Source: BioPlex,STRINGDB
IGHG2
Tdark
p_int: 0.988867972
p_ni: 0.011132026
p_wrong: 1e-9
Data Source: BioPlex
IGKC
Tdark
p_int: 0.984573936
p_ni: 0.015426064
Data Source: BioPlex
FRMD1
Tdark
Novelty: 0.96833141
p_int: 0.978034402
p_ni: 0.021965598
Score: 0.199
Data Source: BioPlex,STRINGDB
IGLL5
Tbio
Novelty: 0.00459259
p_int: 0.955087582
p_ni: 0.005711919
p_wrong: 0.039200499
Score: 0.55
Data Source: BioPlex,STRINGDB
HIST2H2AC
Tbio
Novelty: 0.00065524
p_int: 0.946025016
p_ni: 0.005253233
p_wrong: 0.04872175
Score: 0.194
Data Source: BioPlex,STRINGDB
IGHG1
Tdark
p_int: 0.849849113
p_ni: 0.150150887
Data Source: BioPlex
HSF2
Tbio
Family: TF
Novelty: 0.06458223
p_int: 0.832635877
p_ni: 0.167363464
p_wrong: 6.6e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  185.12

PubMed score by year
PubTator Score  114.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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