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Tbio
SLC7A1
High affinity cationic amino acid transporter 1

Protein Summary
Description
High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380752
  • ENSP00000370128
  • ENSG00000139514

Symbol
  • ATRC1
  • ERR
  • REC1L
  • ERR
  • ATRC1
  • CAT-1
  • HCAT1
  • REC1L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
small molecule perturbation
0.92
microRNA
0.9
PubMedID
0.84
transcription factor binding site profile
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 502.13   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 186   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 502.13   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (108)
RAC3
Tbio
Family:  Enzyme
Novelty:  0.02125361
p_int:  0.999906743
p_ni:  0.000093252
p_wrong:  5e-9
Score:  0.18
Data Source:  BioPlex,STRINGDB
BCL2L13
Tbio
Novelty:  0.01844825
p_int:  0.998521393
p_ni:  0.000001442
p_wrong:  0.001477165
Data Source:  BioPlex
METTL7A
Tbio
Family:  Enzyme
Novelty:  0.10143651
p_int:  0.998198098
p_ni:  0.000297471
p_wrong:  0.00150443
Score:  0.191
Data Source:  BioPlex,STRINGDB
MTCH2
Tbio
Novelty:  0.01794294
p_int:  0.998126788
p_ni:  0.001873191
p_wrong:  2.1e-8
Data Source:  BioPlex
DGAT1
Tclin
Family:  Enzyme
Novelty:  0.00121009
p_int:  0.996837631
p_ni:  0.003031321
p_wrong:  0.000131048
Score:  0.172
Data Source:  BioPlex,STRINGDB
ZDHHC21
Tbio
Family:  Enzyme
Novelty:  0.11768266
p_int:  0.996364248
p_ni:  0.000291367
p_wrong:  0.003344384
Data Source:  BioPlex
TMEM120B
Tdark
Novelty:  1.46242586
p_int:  0.995227507
p_ni:  0.004609102
p_wrong:  0.000163391
Data Source:  BioPlex
TMEM11
Tbio
Novelty:  0.00067837
p_int:  0.993699797
p_ni:  0.006198044
p_wrong:  0.000102159
Data Source:  BioPlex
STX4
Tbio
Novelty:  0.00831588
p_int:  0.993641817
p_ni:  0.006358183
Data Source:  BioPlex
LEMD2
Tbio
Novelty:  0.12460123
p_int:  0.988507166
p_ni:  0.011492834
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Amino acid transport across the plasma membrane (R-HSA-352230)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amino acid transport across the plasma membrane
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Amino acid transport across the plasma membrane
SLC-mediated transmembrane transport
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Diuretic use measurement
1
1
1
42.3
Agents acting on the renin-angiotensin system use measurement
1
1
1
37.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Diuretic use measurement
1
42.3
Agents acting on the renin-angiotensin system use measurement
1
37.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 7 member 1
VGNC:13145
452516
Macaque
solute carrier family 7 member 1
712410
Mouse
MGI:88117
11987
Rat
RGD:3716
25648
Dog
solute carrier family 7 member 1
VGNC:46470
486022
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 7 member 1
Macaque
solute carrier family 7 member 1
Mouse
Rat
Dog
solute carrier family 7 member 1
Publication Statistics
PubMed Score 502.13
PubMed score by year
PubTator Score 566.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title