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Tbio
SERPINB1
Leukocyte elastase inhibitor

Protein Summary
Description
Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Also functions as a potent intracellular inhibitor of granzyme H. The protein encoded by this gene is a member of the serpin family of proteinase inhibitors. Members of this family maintain homeostasis by neutralizing overexpressed proteinase activity through their function as suicide substrates. This protein inhibits the neutrophil-derived proteinases neutrophil elastase, cathepsin G, and proteinase-3 and thus protects tissues from damage at inflammatory sites. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380739
  • ENSP00000370115
  • ENSG00000021355

Symbol
  • ELANH2
  • MNEI
  • PI2
  • EI
  • LEI
  • PI2
  • MNEI
  • PI-2
  • HEL57
  • M/NEI
  • ELANH2
  • HEL-S-27
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
gene perturbation
0.91
PubMedID
0.91
transcription factor perturbation
0.91
disease perturbation
0.9


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 361.12   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 495   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 361.12   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 495   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
2
2
55.2
mean corpuscular volume
1
1
1
27.3
beta-amyloid 1-42 measurement
1
1
1
21.5
monocyte count
1
1
1
12.8
reticulocyte count
1
1
1
6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
55.2
mean corpuscular volume
1
27.3
beta-amyloid 1-42 measurement
1
21.5
monocyte count
1
12.8
reticulocyte count
1
6
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serpin family B member 1
VGNC:9957
471841
Macaque
serpin family B member 1
707471
Mouse
MGI:1913472
66222
Rat
RGD:1306203
291091
Dog
serpin family B member 1 [Source:HGNC Symbol;Acc:HGNC:3311]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serpin family B member 1
Macaque
serpin family B member 1
Mouse
Rat
Dog
serpin family B member 1 [Source:HGNC Symbol;Acc:HGNC:3311]
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P30740-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (51)
1 – 10 of 51
DDX19B
Tbio
Family:  Enzyme
Novelty:  0.0504568
p_int:  0.99932263
p_ni:  0.000677216
p_wrong:  1.55e-7
Score:  0.158
Data Source:  BioPlex,STRINGDB
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.998846604
p_ni:  0.001147725
p_wrong:  0.000005671
Data Source:  BioPlex
KLHL11
Tbio
Novelty:  0.1537041
p_int:  0.997905543
p_ni:  0.002093931
p_wrong:  5.26e-7
Data Source:  BioPlex
CDK15
Tchem
Family:  Kinase
Novelty:  0.3870338
p_int:  0.997849312
p_ni:  0.002150687
p_wrong:  1e-9
Data Source:  BioPlex
ZIC1
Tbio
Family:  TF
Novelty:  0.00491601
p_int:  0.995759847
p_ni:  0.004240153
Data Source:  BioPlex
SOX2
Tbio
Family:  TF
Novelty:  0.00037089
p_int:  0.984018306
p_ni:  0.015981694
Score:  0.201
Data Source:  BioPlex,STRINGDB
GTF2B
Tbio
Novelty:  0.00179492
p_int:  0.983419088
p_ni:  0.016573208
p_wrong:  0.000007704
Score:  0.196
Data Source:  BioPlex,STRINGDB
PRTN3
Tchem
Family:  Enzyme
Novelty:  0.00022728
p_int:  0.981843281
p_ni:  0.017744273
p_wrong:  0.000412446
Score:  0.755
Data Source:  BioPlex,STRINGDB
FSD1
Tbio
Novelty:  0.03452477
p_int:  0.981697989
p_ni:  0.018302011
Data Source:  BioPlex
MUM1
Tbio
Family:  Epigenetic
Novelty:  0.11597088
p_int:  0.970554548
p_ni:  0.02910408
p_wrong:  0.000341372
Data Source:  BioPlex
Publication Statistics
PubMed Score  361.12

PubMed score by year
PubTator Score  113.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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