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Tbio
GSTT1
Glutathione S-transferase theta-1

Protein Summary
Description
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide. The protein encoded by this gene, glutathione S-transferase (GST) theta 1 (GSTT1), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT1 and GSTT2/GSTT2B share 55% amino acid sequence identity and may play a role in human carcinogenesis. The GSTT1 gene is haplotype-specific and is absent from 38% of the population. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000612885
  • ENSP00000481741
  • ENSG00000277656
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
disease
1
chemical
0.93
histone modification site profile
0.7
PubMedID
0.62


Related Tools
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: < 5)
Gene RIFs: 963   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: >= 5)
Gene RIFs: 963   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P30711-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (15)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Glutathione conjugation
Reactome
Metabolism
Reactome
Phase II - Conjugation of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Glutathione conjugation
Metabolism
Phase II - Conjugation of compounds
Protein-Protein Interactions (10)
1 – 10 of 10
MID1
Tbio
Family: Enzyme
Novelty: 0.02400169
p_int: 0.999978266
p_ni: 0.000021727
p_wrong: 8e-9
Data Source: BioPlex
MYLK2
Tchem
Family: Kinase
Novelty: 0.0080273
p_int: 0.999606741
p_ni: 0.000002919
p_wrong: 0.00039034
Data Source: BioPlex
HBB
Tbio
Novelty: 0.00049683
p_int: 0.997444829
p_ni: 0.002555171
Data Source: BioPlex
SIRT2
Tchem
Family: Epigenetic
Novelty: 0.00093962
p_int: 0.990906783
p_ni: 0.008938353
p_wrong: 0.000154865
Data Source: BioPlex
PRSS2
Tchem
Family: Enzyme
Novelty: 0.00959404
p_int: 0.99035641
p_ni: 0.009629669
p_wrong: 0.00001392
Data Source: BioPlex
SPRTN
Tbio
Novelty: 0.0388393
p_int: 0.988320149
p_ni: 0.011679732
p_wrong: 1.19e-7
Data Source: BioPlex
LRP2BP
Tbio
Novelty: 1.73748389
p_int: 0.966344846
p_ni: 0.033655062
p_wrong: 9.1e-8
Data Source: BioPlex
HBA1
Tclin
Novelty: 0.00094113
p_int: 0.964824848
p_ni: 0.035175152
Data Source: BioPlex
LURAP1
Tdark
Novelty: 0.38560236
p_int: 0.829984646
p_ni: 0.000001132
p_wrong: 0.170014221
Data Source: BioPlex
ZMAT5
Tdark
Novelty: 0.97115324
p_int: 0.76961465
p_ni: 0.23038535
Data Source: BioPlex
Publication Statistics
PubTator Score  1146.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer