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Tbio
GNA15
Guanine nucleotide-binding protein subunit alpha-15

Protein Summary
Description
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262958
  • ENSP00000262958
  • ENSG00000060558

Symbol
  • GNA16
  • GNA16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
gene perturbation
0.79
cell type or tissue
0.7
pathway
0.58
protein domain
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 526.76   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 228   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 526.76   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 228   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.1
39.1
monocyte percentage of leukocytes
1
1
1
5.7
mean corpuscular hemoglobin concentration
1
1
1
5.2
neutrophil count
1
1
1
3.3
mean corpuscular volume
1
1
1
1.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
39.1
monocyte percentage of leukocytes
1
5.7
mean corpuscular hemoglobin concentration
1
5.2
neutrophil count
1
3.3
mean corpuscular volume
1
1.5
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:95770
14676
Rat
RGD:619751
89788
Dog
G protein subunit alpha 15
VGNC:41300
485063
Cow
G protein subunit alpha 15
VGNC:29448
532029
Pig
G protein subunit alpha 15
100518537
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
G protein subunit alpha 15
Cow
G protein subunit alpha 15
Pig
G protein subunit alpha 15
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P30679-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (54)
ADP signalling through P2Y purinoceptor 1 (R-HSA-418592)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ADP signalling through P2Y purinoceptor 1
Reactome
Acetylcholine regulates insulin secretion
Reactome
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Reactome
Free fatty acids regulate insulin secretion
Reactome
G alpha (q) signalling events
Name
Explore in Pharos
Explore in Source
ADP signalling through P2Y purinoceptor 1
Acetylcholine regulates insulin secretion
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Free fatty acids regulate insulin secretion
G alpha (q) signalling events
Gene Ontology Terms (14)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (285)
1 – 10 of 285
WDCP
Tdark
Novelty: 0.29184907
p_int: 0.997997341
p_ni: 0.002002659
Score: 0.187
Data Source: BioPlex,STRINGDB
HSPA8
Tchem
Novelty: 0.00081014
p_int: 0.973989968
p_ni: 0.026010032
Score: 0.323
Data Source: BioPlex,STRINGDB
APPBP2
Tbio
Novelty: 0.14742368
p_int: 0.96236103
p_ni: 0.03763828
p_wrong: 6.9e-7
Score: 0.189
Data Source: BioPlex,STRINGDB
FECH
Tbio
Family: Enzyme
Novelty: 0.00282289
p_int: 0.861351616
p_ni: 0.138648384
Score: 0.206
Data Source: BioPlex,STRINGDB
GNB3
Tbio
Novelty: 0.0037117
Score: 0.983
Data Source: STRINGDB
GNB1
Tbio
Novelty: 0.02477955
Score: 0.976
Data Source: Reactome,STRINGDB
GNB2
Tbio
Novelty: 0.08682553
Score: 0.973
Data Source: STRINGDB
GNB4
Tbio
Novelty: 0.08250797
Score: 0.97
Data Source: STRINGDB
GNB5
Tbio
Novelty: 0.0067714
Score: 0.966
Data Source: STRINGDB
GNGT1
Tbio
Novelty: 0.05291961
Score: 0.965
Data Source: STRINGDB
Publication Statistics
PubMed Score  526.76

PubMed score by year
PubTator Score  63.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer