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Tbio
SRI
Sorcin

Protein Summary
Description
Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels. This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene. [provided by RefSeq, Mar 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265729
  • ENSP00000265729
  • ENSG00000075142
  • ENST00000394641
  • ENSP00000378137
  • ENST00000431660
  • ENSP00000391148

Symbol
  • SCN
  • V19
  • CP22
  • CP-22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
interacting protein
0.95
biological process
0.94
kinase perturbation
0.91
transcription factor perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 412.68   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 169   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 412.68   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (62)
1 – 10 of 62
PDCD6IP
Tbio
Novelty:  0.01836118
Score:  0.894
Data Source:  STRINGDB
ANXA7
Tbio
Novelty:  0.00365221
Score:  0.821
Data Source:  STRINGDB
PIR
Tchem
Novelty:  0.00327695
Score:  0.818
Data Source:  STRINGDB
RYR2
Tclin
Family:  IC
Novelty:  0.00078796
Score:  0.78
Data Source:  STRINGDB
PSEN2
Tchem
Family:  Enzyme
Novelty:  0.00112188
Score:  0.78
Data Source:  STRINGDB
HOPX
Tbio
Family:  TF
Novelty:  0.00415501
Score:  0.747
Data Source:  STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.695
Data Source:  STRINGDB
TRDN
Tbio
Novelty:  0.00501554
Score:  0.672
Data Source:  STRINGDB
CAPN15
Tbio
Novelty:  0.01046841
Score:  0.661
Data Source:  STRINGDB
ADGB
Tdark
Novelty:  0.08479527
Score:  0.661
Data Source:  STRINGDB
Pathways (15)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Hemostasis
Reactome
Ion channel transport
Reactome
Ion homeostasis
Reactome
Ion transport by P-type ATPases
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Hemostasis
Ion channel transport
Ion homeostasis
Ion transport by P-type ATPases
Gene Ontology Terms (44)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sorcin
VGNC:4515
463518
Macaque
sorcin
705215
Mouse
MGI:98419
109552
Rat
RGD:1584485
683667
Dog
sorcin
VGNC:46804
475220
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sorcin
Macaque
sorcin
Mouse
Rat
Dog
sorcin
Publication Statistics
PubMed Score 412.68
PubMed score by year
PubTator Score 4646.96
PubTator score by year