Tbio CLIP1 CAP-Gly domain-containing linker protein 1

Protein Summary

Description

Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• P30622
• A0AVD3
• Q17RS4
• Q29RG0

Gene Name

• CLIP1

Ensembl ID

• ENST00000302528
• ENSP00000303585
• ENSG00000130779
• ENST00000358808
• ENSP00000351665
• ENST00000537178
• ENSP00000445531
• ENST00000540338
• ENSP00000439093
• ENST00000620786
• ENSP00000479322

Symbol

• CYLN1
• RSN
• RSN
• CLIP
• CYLN1
• CLIP170
• CLIP-170

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.98
transcription factor perturbation	0.97
drug perturbation	0.96
cellular component	0.92
histone modification site profile	0.9

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Non-motor Microtubule Binding Protein / Cap-gly Domain-containing Linker Protein 1

Protein / Chaperone / Cap-gly Domain-containing Linker Protein 1

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Non-motor Microtubule Binding Protein / Cap-gly Domain-containing Linker Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 288.36   (req: < 5)

Gene RIFs: 47   (req: <= 3)

Antibodies: 281   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 288.36   (req: >= 5)

Gene RIFs: 47   (req: > 3)

Antibodies: 281   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0