You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
OXTR
Oxytocin receptor

Protein Summary
Description
Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316793
  • ENSP00000324270
  • ENSG00000180914

Symbol
  • OT-R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
ligand (chemical)
0.98
biological term
0.95
virus perturbation
0.72
cellular component
0.65


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1394.16   (req: < 5)
Gene RIFs: 265   (req: <= 3)
Antibodies: 360   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1394.16   (req: >= 5)
Gene RIFs: 265   (req: > 3)
Antibodies: 360   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 439
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Approved Drugs (3)
1 – 3 of 3
atosiban
chemical structure image
carbetocin
chemical structure image
oxytocin
chemical structure image
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
oxytocin receptor
VGNC:12118
738742
Macaque
oxytocin receptor
702048
Mouse
MGI:109147
18430
Rat
RGD:3239
25342
Dog
oxytocin receptor
VGNC:44206
484670
Species
Name
OMA
EggNOG
Inparanoid
Chimp
oxytocin receptor
Macaque
oxytocin receptor
Mouse
Rat
Dog
oxytocin receptor
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P30559-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (18)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Gene Ontology Terms (46)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (242)
1 – 10 of 242
OXT
Tbio
Novelty: 0.00005116
Score: 0.997
Data Source: Reactome,STRINGDB
AVP
Tbio
Novelty: 0.00016475
Score: 0.984
Data Source: STRINGDB
NPS
Tbio
Novelty: 0.00692108
Score: 0.966
Data Source: STRINGDB
CCK
Tbio
Novelty: 0.00012268
Score: 0.95
Data Source: STRINGDB
PTGFR
Tclin
Family: GPCR
Novelty: 0.00560908
Score: 0.946
Data Source: STRINGDB
GNAQ
Tbio
Novelty: 0.0008997
Score: 0.945
Data Source: STRINGDB
GNRH2
Tbio
Novelty: 0.0027348
Score: 0.943
Data Source: STRINGDB
NTS
Tbio
Novelty: 0.00033201
Score: 0.943
Data Source: STRINGDB
GNRH1
Tbio
Novelty: 0.00020807
Score: 0.935
Data Source: STRINGDB
TRH
Tbio
Novelty: 0.00052673
Score: 0.934
Data Source: STRINGDB
Publication Statistics
PubMed Score  1394.16

PubMed score by year
PubTator Score  576.96

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: