Tclin OXTR Oxytocin receptor

Protein Summary

Description

Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P30559
• Q15071
• OT-R

Gene Name

• OXTR

Ensembl ID

• ENST00000316793
• ENSP00000324270
• ENSG00000180914

Symbol

• OT-R

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.98
ligand (chemical)	0.98
biological term	0.95
virus perturbation	0.72
cellular component	0.65

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Oxytocin Receptor

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Oxytocin Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1696.48   (req: < 5)

Gene RIFs: 402   (req: <= 3)

Antibodies: 360   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1696.48   (req: >= 5)

Gene RIFs: 402   (req: > 3)

Antibodies: 360   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 614

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4