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Tchem
GRPR
Gastrin-releasing peptide receptor

Protein Summary
Description
Receptor for gastrin-releasing peptide (GRP) (PubMed:1655761). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory (By similarity). Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein c ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380289
  • ENSP00000369643
  • ENSG00000126010

Symbol
  • BB2
  • BB2R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.93
small molecule perturbation
0.64
tissue
0.63
gene perturbation
0.62
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 304.47   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 252   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 304.47   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 252   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 163
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (12)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Protein-Protein Interactions (254)
1 – 10 of 254
F2R
Tclin
Family: GPCR
Novelty: 0.00087698
p_int: 0.999513499
p_ni: 0.000472542
p_wrong: 0.000013959
Score: 0.916
Data Source: BioPlex,STRINGDB
ACVR2B
Tchem
Family: Kinase
Novelty: 0.00693595
p_int: 0.996336238
p_ni: 0.003643281
p_wrong: 0.00002048
Data Source: BioPlex
GJC1
Tbio
Novelty: 0.00506104
p_int: 0.996128368
p_ni: 0.00387162
p_wrong: 1.3e-8
Data Source: BioPlex
CDC42BPB
Tbio
Family: Kinase
Novelty: 0.23112171
p_int: 0.995706974
p_ni: 0.004293026
Score: 0.156
Data Source: BioPlex,STRINGDB
USP30
Tbio
Family: Enzyme
Novelty: 0.0478459
p_int: 0.994396008
p_ni: 0.005603979
p_wrong: 1.3e-8
Data Source: BioPlex
HCCS
Tbio
Family: Enzyme
Novelty: 0.00043239
p_int: 0.994393474
p_ni: 0.005606521
p_wrong: 5e-9
Score: 0.48
Data Source: BioPlex,STRINGDB
SLC6A8
Tbio
Family: Transporter
Novelty: 0.00421329
p_int: 0.994310264
p_ni: 0.005430697
p_wrong: 0.000259039
Score: 0.162
Data Source: BioPlex,STRINGDB
ASPHD2
Tdark
Family: Enzyme
Novelty: 4
p_int: 0.993604233
p_ni: 0.006395745
p_wrong: 2.3e-8
Data Source: BioPlex
ARL8B
Tbio
Family: Enzyme
Novelty: 0.08537963
p_int: 0.989512908
p_ni: 0.010288045
p_wrong: 0.000199046
Data Source: BioPlex
RAB4A
Tbio
Family: Enzyme
Novelty: 0.00612015
p_int: 0.988863196
p_ni: 0.009762103
p_wrong: 0.001374701
Score: 0.2
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  304.47

PubMed score by year
PubTator Score  300.24

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
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