You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
ADORA1
Adenosine receptor A1

Protein Summary
Description
Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309502
  • ENSP00000308549
  • ENSG00000163485
  • ENST00000337894
  • ENSP00000338435
  • ENST00000367235
  • ENSP00000356204
  • ENST00000367236
  • ENSP00000356205
  • ENST00000640524
  • ENSP00000491900

Symbol
  • RDC7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
ligand (chemical)
1
molecular function
0.96
transcription factor perturbation
0.91
PubMedID
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2377.57   (req: < 5)
Gene RIFs: 82   (req: <= 3)
Antibodies: 455   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2377.57   (req: >= 5)
Gene RIFs: 82   (req: > 3)
Antibodies: 455   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 57
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1235
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
5
0
1
68.2
childhood onset asthma
2
1
0
1.1
66.6
systolic blood pressure
1
1
1
30
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1
68.2
childhood onset asthma
0
1.1
66.6
systolic blood pressure
1
30
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adenosine A1 receptor
VGNC:10535
457638
Macaque
adenosine A1 receptor
703638
Mouse
MGI:99401
11539
Rat
RGD:2048
29290
Dog
adenosine A1 receptor
VGNC:37665
403961
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adenosine A1 receptor
Macaque
adenosine A1 receptor
Mouse
Rat
Dog
adenosine A1 receptor
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P30542-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (32)
Adenosine P1 receptors (R-HSA-417973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adenosine P1 receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Adenosine P1 receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (70)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (316)
1 – 10 of 316
GNAI2
Tbio
Novelty: 0.03014729
Score: 0.988
Data Source: STRINGDB
GNB1
Tbio
Novelty: 0.02477955
Score: 0.982
Data Source: STRINGDB
GNG2
Tbio
Novelty: 0.04807242
Score: 0.981
Data Source: STRINGDB
P2RY12
Tclin
Family: GPCR
Novelty: 0.00035406
Score: 0.958
Data Source: STRINGDB
P2RY4
Tchem
Family: GPCR
Novelty: 0.00903213
Score: 0.956
Data Source: STRINGDB
P2RY13
Tchem
Family: GPCR
Novelty: 0.01511227
Score: 0.95
Data Source: STRINGDB
GABBR1
Tclin
Family: GPCR
Novelty: 0.00086493
Score: 0.946
Data Source: STRINGDB
P2RY14
Tchem
Family: GPCR
Novelty: 0.0135462
Score: 0.946
Data Source: STRINGDB
KNG1
Tchem
Novelty: 0.00007684
Score: 0.945
Data Source: STRINGDB
ADCY5
Tchem
Family: Enzyme
Novelty: 0.00307839
Score: 0.944
Data Source: STRINGDB
Publication Statistics
PubMed Score  2377.57

PubMed score by year
PubTator Score  190.3

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: