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Tchem
TSPO
Translocator protein

Protein Summary
Description
Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:24814875), but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides (PubMed:1847678). Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein. [provided b ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329563
  • ENSP00000328973
  • ENSG00000100300
  • ENST00000337554
  • ENSP00000338004
  • ENST00000396265
  • ENSP00000379563

Symbol
  • BZRP
  • MBR
  • DBI
  • IBP
  • MBR
  • PBR
  • PBS
  • BPBS
  • BZRP
  • PKBS
  • PTBR
  • mDRC
  • pk18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
disease perturbation
1
cellular component
0.97
transcription factor perturbation
0.91
kinase perturbation
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2706.71   (req: < 5)
Gene RIFs: 116   (req: <= 3)
Antibodies: 248   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2706.71   (req: >= 5)
Gene RIFs: 116   (req: > 3)
Antibodies: 248   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 78
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
alpidem
Rendered image for alpidem
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
2
4
88.7
monocyte percentage of leukocytes
2
2
4
88.7
monocyte count
2
2
4
88.6
monocyte count
2
2
4
88.6
1
2
0
1.2
71.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
4
88.7
monocyte percentage of leukocytes
4
88.7
monocyte count
4
88.6
monocyte count
4
88.6
0
1.2
71.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
translocator protein
VGNC:5988
458887
Macaque
translocator protein
711717
Mouse
MGI:88222
12257
Rat
RGD:2228
24230
Dog
translocator protein
VGNC:54552
474475
Species
Name
OMA
EggNOG
Inparanoid
Chimp
translocator protein
Macaque
translocator protein
Mouse
Rat
Dog
translocator protein
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P30536-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroid hormones
Reactome
Metabolism of steroids
Reactome
Pregnenolone biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Metabolism of steroid hormones
Metabolism of steroids
Pregnenolone biosynthesis
Gene Ontology Terms (45)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (76)
1 – 10 of 76
CRABP1
Tbio
Novelty:  0.00284292
p_int:  0.998046709
p_ni:  0.001953291
Score:  0.485
Data Source:  BioPlex,STRINGDB
SLC2A12
Tbio
Family:  Transporter
Novelty:  0.01455533
p_int:  0.991838937
p_ni:  0.004544996
p_wrong:  0.003616068
Score:  0.208
Data Source:  BioPlex,STRINGDB
SLC5A8
Tchem
Family:  Transporter
Novelty:  0.00892277
p_int:  0.991838937
p_ni:  0.004544996
p_wrong:  0.003616068
Score:  0.197
Data Source:  BioPlex,STRINGDB
VDAC1
Tbio
Novelty:  0.0011441
Score:  0.981
Data Source:  STRINGDB
TSPOAP1
Tbio
Novelty:  0.10247675
Score:  0.976
Data Source:  Reactome,STRINGDB
VDAC3
Tbio
Novelty:  0.0095068
Score:  0.952
Data Source:  STRINGDB
VDAC2
Tchem
Novelty:  0.00575936
Score:  0.944
Data Source:  STRINGDB
SLC25A6
Tchem
Family:  Transporter
Novelty:  0.0052748
Score:  0.897
Data Source:  STRINGDB
SLC25A5
Tchem
Family:  Transporter
Novelty:  0.00749909
Score:  0.882
Data Source:  STRINGDB
SLC25A4
Tbio
Family:  Transporter
Novelty:  0.01250865
Score:  0.874
Data Source:  STRINGDB
Publication Statistics
PubMed Score  2706.71

PubMed score by year
PubTator Score  1155.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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