Tbio LRPAP1 Alpha-2-macroglobulin receptor-associated protein

Protein Summary

Description

Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway. This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Uniprot Accession IDs

• P30533
• D3DVR9
• Q2M310
• Q53HQ3
• Q53HS6
• Alpha-2-MRAP

Gene Name

• LRPAP1

Ensembl ID

• ENST00000500728
• ENSP00000421922
• ENSG00000163956
• ENST00000650182
• ENSP00000497444

Symbol

• A2MRAP
• RAP
• MRAP
• A2RAP
• HBP44
• MYP23
• A2MRAP
• alpha-2-MRAP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
disease perturbation	0.96
transcription factor perturbation	0.96
PubMedID	0.94
virus perturbation	0.92

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 545.01   (req: < 5)

Gene RIFs: 33   (req: <= 3)

Antibodies: 459   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 545.01   (req: >= 5)

Gene RIFs: 33   (req: > 3)

Antibodies: 459   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0