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Tbio
CHRNA5
Neuronal acetylcholine receptor subunit alpha-5

Protein Summary
Description
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).[provided by RefSeq, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299565
  • ENSP00000299565
  • ENSG00000169684

Symbol
  • NACHRA5
  • LNCR2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
protein domain
0.85
biological term
0.84
molecular function
0.84
gene perturbation
0.69


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 304.64   (req: < 5)
Gene RIFs: 160   (req: <= 3)
Antibodies: 308   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 304.64   (req: >= 5)
Gene RIFs: 160   (req: > 3)
Antibodies: 308   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (70)
CHRNB4
Tclin
Family:  IC
Novelty:  0.01151716
p_int:  0.982648492
p_ni:  0.017351508
Score:  0.956
Data Source:  BioPlex,Reactome,STRINGDB
DEFA1
Tbio
Novelty:  0.01027492
p_int:  0.943292845
p_ni:  0.056707151
p_wrong:  4e-9
Data Source:  BioPlex
TMEM30A
Tbio
Novelty:  0.05115559
p_int:  0.827690066
p_ni:  0.172309934
Score:  0.169
Data Source:  BioPlex,STRINGDB
SLAMF1
Tbio
Novelty:  0.00112892
p_int:  0.822099955
p_ni:  0.177900045
Data Source:  BioPlex
ADGRG5
Tdark
Family:  GPCR
Novelty:  0.26575982
p_int:  0.786908518
p_ni:  0.213091482
Data Source:  BioPlex
CHRNA3
Tclin
Family:  IC
Novelty:  0.00659767
Score:  0.961
Data Source:  Reactome,STRINGDB
CHRNB2
Tclin
Family:  IC
Novelty:  0.01251655
Score:  0.956
Data Source:  Reactome,STRINGDB
CHRNA4
Tclin
Family:  IC
Novelty:  0.00494934
Score:  0.943
Data Source:  STRINGDB
CHRNA2
Tchem
Family:  IC
Novelty:  0.02542208
Score:  0.942
Data Source:  STRINGDB
CHRNA6
Tchem
Family:  IC
Novelty:  0.03991261
Score:  0.929
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Acetylcholine binding and downstream events (R-HSA-181431)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acetylcholine binding and downstream events
Reactome
Highly calcium permeable nicotinic acetylcholine receptors
Reactome
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Name
Explore in Pharos
Explore in Source
Acetylcholine binding and downstream events
Highly calcium permeable nicotinic acetylcholine receptors
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (45)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cigarettes per day measurement
8
12
16
99.9
13
7
1
1.3
99.7
14
12
4
1.3
99.3
3
3
3
99.2
smoking behaviour measurement
3
4
3
1.3
98.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cigarettes per day measurement
16
99.9
1
1.3
99.7
4
1.3
99.3
3
99.2
smoking behaviour measurement
3
1.3
98.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cholinergic receptor nicotinic alpha 5 subunit
VGNC:10796
619369
Macaque
cholinergic receptor nicotinic alpha 5 subunit
574191
Mouse
MGI:87889
110835
Rat
RGD:2347
25102
Dog
cholinergic receptor nicotinic alpha 5 subunit
VGNC:49739
482112
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cholinergic receptor nicotinic alpha 5 subunit
Macaque
cholinergic receptor nicotinic alpha 5 subunit
Mouse
Rat
Dog
cholinergic receptor nicotinic alpha 5 subunit
Publication Statistics
PubMed Score 304.64
PubMed score by year
PubTator Score 145.76
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title