Tclin SLC6A1 Sodium- and chloride-dependent GABA transporter 1

Protein Summary

Description

Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals. The protein encoded by this gene is a gamma-aminobutyric acid (GABA) transporter that localizes to the plasma membrane. The encoded protein removes GABA from the synaptic cleft, restoring it to presynaptic terminals. [provided by RefSeq, Jan 2017]

Uniprot Accession IDs

• P30531
• Q8N4K8
• GAT-1

Gene Name

• SLC6A1

Ensembl ID

• ENST00000287766
• ENSP00000287766
• ENSG00000157103
• ENST00000642201
• ENSP00000494778
• ENST00000642515
• ENSP00000496348
• ENST00000642639
• ENSP00000494191
• ENST00000642735
• ENSP00000494050
• ENST00000642767
• ENSP00000494346
• ENST00000642820
• ENSP00000495900
• ENST00000643396
• ENSP00000494136
• ENST00000643498
• ENSP00000494997
• ENST00000645029
• ENSP00000496171
• ENST00000645054
• ENSP00000495751
• ENST00000645592
• ENSP00000496619
• ENST00000645974
• ENSP00000496390
• ENST00000646022
• ENSP00000494134
• ENST00000646060
• ENSP00000496302
• ENST00000646570
• ENSP00000496064
• ENST00000646702
• ENSP00000496697
• ENST00000646924
• ENSP00000493591
• ENST00000647194
• ENSP00000496238

Symbol

• GABATR
• GABT1
• GAT1
• MAE
• GAT1
• GABATR
• GABATHG

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.93
gene perturbation	0.84
biological process	0.82
microRNA	0.73
PubMedID	0.66

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Sodium- And Chloride-dependent Gaba Transporter 1

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc6 Neurotransmitter Transporter Family / Gaba Transporter Subfamily / Sodium- And Chloride-dependent Gaba Transporter 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 678.64   (req: < 5)

Gene RIFs: 55   (req: <= 3)

Antibodies: 236   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 678.64   (req: >= 5)

Gene RIFs: 55   (req: > 3)

Antibodies: 236   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 56

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1