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Tchem
AXL
Tyrosine-protein kinase receptor UFO

Protein Summary
Description
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301178
  • ENSP00000301178
  • ENSG00000167601
  • ENST00000359092
  • ENSP00000351995

Symbol
  • UFO
  • ARK
  • UFO
  • JTK11
  • Tyro7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
protein domain
1
transcription factor perturbation
0.96
small molecule
0.95


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 896.11   (req: < 5)
Gene RIFs: 227   (req: <= 3)
Antibodies: 1015   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 896.11   (req: >= 5)
Gene RIFs: 227   (req: > 3)
Antibodies: 1015   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 47
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
Active Ligands (47)
1 – 10 of 47
CHEMBL388978
chemical structure image
CHEMBL1230609
chemical structure image
CHEMBL509032
chemical structure image
CHEMBL1908395,CHEMBL1908842
chemical structure image
sitravatinib
chemical structure image
RIPK1 inhibitor 22b
chemical structure image
CHEMBL3326006
chemical structure image
CHEMBL3545307
chemical structure image
compound 19a [PMID: 30503936]
chemical structure image
CHEMBL2172308
chemical structure image
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
86.8
mean corpuscular hemoglobin concentration
1
1
1
70.8
triglyceride measurement
1
1
1
19.7
mean corpuscular volume
1
1
1
17.5
electrocardiography
1
1
1
16
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
86.8
mean corpuscular hemoglobin concentration
1
70.8
triglyceride measurement
1
19.7
mean corpuscular volume
1
17.5
electrocardiography
1
16
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
AXL receptor tyrosine kinase
VGNC:2098
456057
Macaque
AXL receptor tyrosine kinase
706123
Mouse
MGI:1347244
26362
Rat
RGD:620028
308444
Dog
AXL receptor tyrosine kinase
VGNC:38326
484490
Species
Name
OMA
EggNOG
Inparanoid
Chimp
AXL receptor tyrosine kinase
Macaque
AXL receptor tyrosine kinase
Mouse
Rat
Dog
AXL receptor tyrosine kinase
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P30530-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (20)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by Receptor Tyrosine Kinases
Reactome
Signaling by VEGF
Reactome
VEGFA-VEGFR2 Pathway
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by Receptor Tyrosine Kinases
Signaling by VEGF
VEGFA-VEGFR2 Pathway
Gene Ontology Terms (59)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (107)
1 – 10 of 107
GAS6
Tbio
Novelty: 0.00297606
Score: 0.998
Data Source: STRINGDB
PIK3CA
Tclin
Family: Kinase
Novelty: 0.00044273
Score: 0.948
Data Source: Reactome,STRINGDB
PIK3R1
Tchem
Family: Kinase
Novelty: 0.00179772
Score: 0.945
Data Source: Reactome,STRINGDB
PIK3R2
Tbio
Family: Enzyme
Novelty: 0.00829659
Score: 0.94
Data Source: Reactome,STRINGDB
VAV1
Tchem
Novelty: 0.00180518
Score: 0.93
Data Source: STRINGDB
KDR
Tclin
Family: Kinase
Novelty: 0.00016219
Score: 0.928
Data Source: Reactome,STRINGDB
SHC1
Tchem
Novelty: 0.00083615
Score: 0.924
Data Source: STRINGDB
VAV2
Tbio
Novelty: 0.01062502
Score: 0.914
Data Source: STRINGDB
VAV3
Tbio
Novelty: 0.010944
Score: 0.914
Data Source: STRINGDB
PIK3CB
Tchem
Family: Kinase
Novelty: 0.00390277
Score: 0.913
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  896.11

PubMed score by year
PubTator Score  643.33

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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