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Tchem
ADSS
Adenylosuccinate synthetase isozyme 2

Protein Summary
Description
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. This gene encodes the enzyme adenylosuccinate synthetase which catalyzes the first committed step in the conversion of inosine monophosphate to adenosine monophosphate. A pseudogene of this gene is found on chromosome 17.[provided by RefSeq, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366535
  • ENSP00000355493
  • ENSG00000035687

Symbol
  • ADSS2
  • ADEH
  • ADSS 2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
disease perturbation
0.87
transcription factor binding site profile
0.85
biological process
0.69
transcription factor perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.89   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 140   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.89   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (151)
1 – 10 of 151
ADSSL1
Tbio
Family:  Enzyme
Novelty:  0.0511949
p_int:  0.999996356
p_ni:  0.000003644
p_wrong:  1e-9
Score:  0.94
Data Source:  BioPlex,STRINGDB
SMYD1
Tbio
Family:  Epigenetic
Novelty:  0.03781475
p_int:  0.99998102
p_ni:  0.00001898
Score:  0.487
Data Source:  BioPlex,STRINGDB
NPB
Tdark
Novelty:  0.00936692
p_int:  0.987273976
p_ni:  0.012726024
Score:  0.189
Data Source:  BioPlex,STRINGDB
LGALS7
Tbio
Novelty:  0.00753996
p_int:  0.928441805
p_ni:  0.071558195
Data Source:  BioPlex
ADSL
Tbio
Family:  Enzyme
Novelty:  0.0028496
Score:  0.994
Data Source:  STRINGDB
ASS1
Tbio
Family:  Enzyme
Novelty:  0.00358761
Score:  0.986
Data Source:  STRINGDB
ITPA
Tbio
Family:  Enzyme
Novelty:  0.00235169
Score:  0.985
Data Source:  STRINGDB
ATIC
Tchem
Novelty:  0.00466845
Score:  0.983
Data Source:  STRINGDB
HPRT1
Tchem
Family:  Enzyme
Novelty:  0.00032232
Score:  0.97
Data Source:  STRINGDB
AMPD1
Tchem
Family:  Enzyme
Novelty:  0.00486439
Score:  0.969
Data Source:  STRINGDB
Pathways (25)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleobase biosynthesis
Reactome
Purine ribonucleoside monophosphate biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleobase biosynthesis
Purine ribonucleoside monophosphate biosynthesis
Gene Ontology Terms (17)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
2
2
74.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
74.7
Find similar targets by:
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adenylosuccinate synthase
VGNC:10536
457865
Macaque
adenylosuccinate synthase
713580
Mouse
MGI:87948
11566
Rat
RGD:1310508
289276
Dog
adenylosuccinate synthase
VGNC:37679
480098
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adenylosuccinate synthase
Macaque
adenylosuccinate synthase
Mouse
Rat
Dog
adenylosuccinate synthase
Publication Statistics
PubMed Score 89.89
PubMed score by year
PubTator Score 26.88
PubTator score by year