Protein Summary
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter. Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. Several alternatively spliced transcript variants encoding three different isoforms have been found for thi ...more
- ENST00000219700
- ENSP00000219700
- ENSG00000103415
- ENST00000398595
- ENSP00000381595
- ENST00000406590
- ENSP00000385100
- ENST00000414777
- ENSP00000391637
- ENST00000458134
- ENSP00000394103
- ENST00000570646
- ENSP00000459214
- ENST00000575120
- ENSP00000460926
- ENST00000612525
- ENSP00000481295
- ENSG00000277424
- ENST00000615778
- ENSP00000484422
- ENST00000619528
- ENSP00000484423
- ENST00000619913
- ENSP00000484467
- ENST00000620445
- ENSP00000478785
- ENST00000621065
- ENSP00000481811
- ENST00000622146
- ENSP00000483319
- ENST00000631540
- ENSP00000487673
- ENST00000631677
- ENSP00000488579
- ENST00000632458
- ENSP00000488880
- ENST00000633319
- ENSP00000488769
- HO2
- HO-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.99 | ||
virus perturbation | 0.88 | ||
kinase perturbation | 0.84 | ||
transcription factor | 0.71 | ||
transcription factor binding site profile | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 561.74 (req: < 5)
Gene RIFs: 51 (req: <= 3)
Antibodies: 512 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 561.74 (req: >= 5)
Gene RIFs: 51 (req: > 3)
Antibodies: 512 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 3
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0