Protein Summary
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter. Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. Several alternatively spliced transcript variants encoding three different isoforms have been found for thi ...more
- ENST00000219700
- ENSP00000219700
- ENSG00000103415
- ENST00000398595
- ENSP00000381595
- ENST00000406590
- ENSP00000385100
- ENST00000414777
- ENSP00000391637
- ENST00000458134
- ENSP00000394103
- ENST00000570646
- ENSP00000459214
- ENST00000575120
- ENSP00000460926
- ENST00000612525
- ENSP00000481295
- ENSG00000277424
- ENST00000615778
- ENSP00000484422
- ENST00000619528
- ENSP00000484423
- ENST00000619913
- ENSP00000484467
- ENST00000620445
- ENSP00000478785
- ENST00000621065
- ENSP00000481811
- ENST00000622146
- ENSP00000483319
- ENST00000631540
- ENSP00000487673
- ENST00000631677
- ENSP00000488579
- ENST00000632458
- ENSP00000488880
- ENST00000633319
- ENSP00000488769
- HO2
- HO-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.99 | ||
virus perturbation | 0.88 | ||
kinase perturbation | 0.84 | ||
transcription factor | 0.71 | ||
transcription factor binding site profile | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 513.3 (req: < 5)
Gene RIFs: 44 (req: <= 3)
Antibodies: 512 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 513.3 (req: >= 5)
Gene RIFs: 44 (req: > 3)
Antibodies: 512 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 3
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (3)
Protein-Protein Interactions (195)
POTEE
Novelty: 0.29349205
p_int: 0.999956703
p_ni: 0.000043022
p_wrong: 2.74e-7
Score: 0.204
Data Source: BioPlex,STRINGDB
ALG2
Family: Enzyme
Novelty: 0.03804805
p_int: 0.999793775
p_ni: 0.00012655
p_wrong: 0.000079675
Score: 0.233
Data Source: BioPlex,STRINGDB
UGT8
Family: Enzyme
Novelty: 0.02518383
p_int: 0.999771249
p_ni: 0.000228751
Score: 0.225
Data Source: BioPlex,STRINGDB
HTR2C
Family: GPCR
Novelty: 0.00074287
p_int: 0.998820445
p_ni: 0.001179555
Data Source: BioPlex
ADPGK
Family: Kinase
Novelty: 0.0552414
p_int: 0.995220688
p_ni: 0.004779312
Score: 0.449
Data Source: BioPlex,STRINGDB
C3AR1
Family: GPCR
Novelty: 0.00527301
p_int: 0.990048761
p_ni: 0.009951239
Score: 0.908
Data Source: BioPlex,STRINGDB
PRAF2
Novelty: 0.04605835
p_int: 0.959253283
p_ni: 0.040706905
p_wrong: 0.000039812
Data Source: BioPlex
GNB2
Novelty: 0.08682553
p_int: 0.957317575
p_ni: 0.042682408
p_wrong: 1.7e-8
Data Source: BioPlex
VIPR2
Family: GPCR
Novelty: 0.00463802
p_int: 0.947569679
p_ni: 0.052430321
Data Source: BioPlex
Nearest Tclin Targets
Pathways (11)
Reactome (8)
KEGG (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Heme degradation | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Iron uptake and transport | ||||
Reactome | Metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Heme degradation | ||||
Immune System | ||||
Innate Immune System | ||||
Iron uptake and transport | ||||
Metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (3)
Components (4)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (18)
Items per page:
1 – 5 of 18
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 9 | 10 | 19 | 91.1 | |||||
waist-hip ratio | 4 | 7 | 8 | 79.4 | |||||
heel bone mineral density | 2 | 3 | 5 | 76.5 | |||||
BMI-adjusted hip circumference | 2 | 4 | 4 | 75.8 | |||||
triglyceride measurement | 1 | 1 | 1 | 60.5 | |||||
Items per page:
1 – 5 of 18
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 19 | 91.1 | |||||
waist-hip ratio | 8 | 79.4 | |||||
heel bone mineral density | 5 | 76.5 | |||||
BMI-adjusted hip circumference | 4 | 75.8 | |||||
triglyceride measurement | 1 | 60.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | heme oxygenase 2 | VGNC:13713 | 453880 | |||||
Macaque | heme oxygenase 2 | 705461 | ||||||
Mouse | MGI:109373 | 15369 | ||||||
Rat | RGD:67402 | 79239 | ||||||
Dog | heme oxygenase 2 | VGNC:41720 | 479864 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | heme oxygenase 2 | |||||
Macaque | heme oxygenase 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | heme oxygenase 2 | |||||
Publication Statistics
PubMed Score 513.30
PubMed score by year
PubTator Score 639.64
PubTator score by year
Related Publications
Text Mined References (66)
GeneRif Annotations (44)
Items per page:
0 of 0
PMID | Year | Title |
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