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Tclin
AVPR2
Vasopressin V2 receptor

Protein Summary
Description
Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption. This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the functi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337474
  • ENSP00000338072
  • ENSG00000126895
  • ENST00000358927
  • ENSP00000351805
  • ENST00000370049
  • ENSP00000359066
  • ENST00000646375
  • ENSP00000496396

Symbol
  • ADHR
  • DIR
  • DIR3
  • V2R
  • DI1
  • DIR
  • NDI
  • V2R
  • ADHR
  • DIR3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
1
biological process
0.91
tissue
0.63
biological term
0.6
cellular component
0.6


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1081.61   (req: < 5)
Gene RIFs: 87   (req: <= 3)
Antibodies: 262   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1081.61   (req: >= 5)
Gene RIFs: 87   (req: > 3)
Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 341
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
arginine vasopressin receptor 2
VGNC:1407
742565
Mouse
MGI:88123
12000
Rat
RGD:2186
25108
Dog
arginine vasopressin receptor 2
VGNC:38320
403804
Horse
arginine vasopressin receptor 2
VGNC:15712
100059066
Species
Name
OMA
EggNOG
Inparanoid
Chimp
arginine vasopressin receptor 2
Mouse
Rat
Dog
arginine vasopressin receptor 2
Horse
arginine vasopressin receptor 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P30518-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (25)
Aquaporin-mediated transport (R-HSA-445717)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aquaporin-mediated transport
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Clathrin-mediated endocytosis
Reactome
Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)
Name
Explore in Pharos
Explore in Source
Aquaporin-mediated transport
Cargo recognition for clathrin-mediated endocytosis
Class A/1 (Rhodopsin-like receptors)
Clathrin-mediated endocytosis
Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)
Gene Ontology Terms (28)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (322)
1 – 10 of 322
AVP
Tbio
Novelty: 0.00016475
Score: 0.987
Data Source: Reactome,STRINGDB
ARRB1
Tbio
Novelty: 0.00262758
Score: 0.977
Data Source: Reactome,STRINGDB
ARRB2
Tbio
Novelty: 0.00148149
Score: 0.966
Data Source: Reactome,STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.957
Data Source: Reactome,STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.957
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.957
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.957
Data Source: STRINGDB
GNG2
Tbio
Novelty: 0.04807242
Score: 0.95
Data Source: STRINGDB
GNB1
Tbio
Novelty: 0.02477955
Score: 0.95
Data Source: STRINGDB
GRK2
Tchem
Family: Kinase
Novelty: 0.00200696
Score: 0.946
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  1081.61

PubMed score by year
PubTator Score  670.89

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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