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Tbio
HLA-F
HLA class I histocompatibility antigen, alpha chain F

Protein Summary
Description
Involved in the presentation of foreign antigens to the immune system. This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259951
  • ENSP00000259951
  • ENSG00000204642
  • ENST00000334668
  • ENSP00000334263
  • ENST00000359076
  • ENSP00000351977
  • ENSG00000206509
  • ENST00000376848
  • ENSP00000366044
  • ENSG00000229698
  • ENST00000376861
  • ENSP00000366057
  • ENST00000383515
  • ENSP00000373007
  • ENSG00000137403
  • ENST00000420067
  • ENSP00000393535
  • ENSG00000235220
  • ENST00000434407
  • ENSP00000397376
  • ENST00000440590
  • ENSP00000399835
  • ENSG00000237508

Symbol
  • HLA-5.4
  • HLAF
  • HLAF
  • CDA12
  • HLA-5.4
  • HLA-CDA12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
protein domain
0.97
PubMedID
0.94
disease perturbation
0.79
phenotype
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.16   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.16   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (247)
1 – 10 of 247
HLA-G
Tbio
Novelty:  0.0009462
p_int:  0.997522974
p_ni:  0.002477026
Score:  0.987
Data Source:  BioPlex,STRINGDB
KDM5C
Tchem
Family:  TF; Epigenetic
Novelty:  0.00701855
p_int:  0.995361316
p_ni:  0.003245896
p_wrong:  0.001392788
Score:  0.205
Data Source:  BioPlex,STRINGDB
HLA-C
Tbio
Novelty:  0.00698601
p_int:  0.989762104
p_ni:  0.010237896
Score:  0.969
Data Source:  BioPlex,STRINGDB
PTPRN
Tbio
Family:  Enzyme
Novelty:  0.00076479
p_int:  0.98185816
p_ni:  0.01814184
Score:  0.188
Data Source:  BioPlex,STRINGDB
KIAA1549
Tbio
Novelty:  0.01224835
p_int:  0.906690684
p_ni:  0.000345567
p_wrong:  0.092963749
Score:  0.228
Data Source:  BioPlex,STRINGDB
HLA-E
Tbio
Novelty:  0.00216583
p_int:  0.891119177
p_ni:  0.108880823
Score:  0.969
Data Source:  BioPlex,STRINGDB
IL17RB
Tbio
Novelty:  0.01540031
p_int:  0.858332911
p_ni:  0.141667089
Score:  0.181
Data Source:  BioPlex,STRINGDB
CD1A
Tbio
Novelty:  0.00090676
p_int:  0.849305586
p_ni:  0.150694414
Score:  0.198
Data Source:  BioPlex,STRINGDB
GRIA3
Tclin
Family:  IC
Novelty:  0.00584546
p_int:  0.792018885
p_ni:  0.207981115
Score:  0.163
Data Source:  BioPlex,STRINGDB
B2M
Tbio
Novelty:  0.00011248
Score:  0.998
Data Source:  STRINGDB
Pathways (33)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Reactome
Antigen processing-Cross presentation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen processing-Cross presentation
Class I MHC mediated antigen processing & presentation
Cytokine Signaling in Immune system
Gene Ontology Terms (24)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
GWAS Traits (240)
Items per page:
1 – 5 of 240
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
2
3
3
89.4
eosinophil percentage of leukocytes
2
3
3
89.4
eosinophil percentage of leukocytes
2
3
3
89.4
eosinophil percentage of leukocytes
2
3
3
89.4
eosinophil percentage of leukocytes
2
3
3
89.4
Items per page:
1 – 5 of 240
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
3
89.4
eosinophil percentage of leukocytes
3
89.4
eosinophil percentage of leukocytes
3
89.4
eosinophil percentage of leukocytes
3
89.4
eosinophil percentage of leukocytes
3
89.4
Find similar targets by:
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
major histocompatibility complex, class I, F
709076
Mouse
MGI:95935
110557
Rat
RGD:1595868
309607
Species
Name
OMA
EggNOG
Inparanoid
Macaque
major histocompatibility complex, class I, F
Mouse
Rat
Publication Statistics
PubMed Score 99.16
PubMed score by year
PubTator Score 72.00
PubTator score by year