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Tbio
HLA-B
HLA class I histocompatibility antigen, B-53 alpha chain

Protein Summary
Description
Involved in the presentation of foreign antigens to the immune system. HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4129.45   (req: < 5)
Gene RIFs: 821   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4129.45   (req: >= 5)
Gene RIFs: 821   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2910)
Items per page:
1 – 5 of 2910
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
4
0
2.8
99.9
7
4
0
2.8
99.9
7
4
0
2.8
99.9
7
4
0
2.8
99.9
7
4
0
2.8
99.9
Items per page:
1 – 5 of 2910
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2.8
99.9
0
2.8
99.9
0
2.8
99.9
0
2.8
99.9
0
2.8
99.9
Protein Structure (2 Structures, 0 AlphaFold Models)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (42)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Reactome
Antigen processing-Cross presentation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen processing-Cross presentation
Class I MHC mediated antigen processing & presentation
Cytokine Signaling in Immune system
Gene Ontology Terms (18)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (272)
1 – 10 of 272
CD1A
Tbio
Novelty: 0.00090676
p_int: 0.95709585
p_ni: 0.04290415
Score: 0.172
Data Source: BioPlex,STRINGDB
SLC3A2
Tbio
Family: Transporter
Novelty: 0.0021506
p_int: 0.885460392
p_ni: 0.114539608
Data Source: BioPlex
PSCA
Tbio
Novelty: 0.00323778
p_int: 0.865253887
p_ni: 0.134746113
Data Source: BioPlex
PATE1
Tbio
Novelty: 0.0705075
p_int: 0.86099351
p_ni: 0.139006491
Data Source: BioPlex
CHRNB4
Tclin
Family: IC
Novelty: 0.01151716
p_int: 0.847407371
p_ni: 0.152592629
Data Source: BioPlex
SGSH
Tbio
Family: Enzyme
Novelty: 0.00670111
p_int: 0.840506735
p_ni: 0.159493265
Data Source: BioPlex
CLEC4A
Tbio
Novelty: 0.01821643
p_int: 0.824041681
p_ni: 0.175958319
Data Source: BioPlex
CLEC4C
Tbio
Novelty: 0.00845053
p_int: 0.767627528
p_ni: 0.232372472
Data Source: BioPlex
B2M
Tbio
Novelty: 0.00011248
Score: 0.999
Data Source: STRINGDB
KIR3DL1
Tbio
Novelty: 0.00308245
Score: 0.992
Data Source: STRINGDB
Publication Statistics
PubMed Score  4129.45

PubMed score by year
PubTator Score  8017.41

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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