You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
NMT1
Glycylpeptide N-tetradecanoyltransferase 1

Protein Classes
Protein Summary
Description
Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1; MIM 139311) (Duronio et al., 1992 [PubMed 1570339]).[supplied by OMIM, Nov 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258960
  • ENSP00000258960
  • ENSG00000136448
  • ENST00000592782
  • ENSP00000468424

Symbol
  • NMT
  • NMT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
virus perturbation
1
kinase perturbation
0.84
transcription factor binding site profile
0.83
transcription factor perturbation
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 295.18   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 295.18   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 205
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
insomnia measurement
1
2
0
1
82
systolic blood pressure
1
1
1
69.9
multisite chronic pain
1
1
1
29
white matter hyperintensity measurement
1
1
1
22.7
platelet crit
1
1
1
16.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
insomnia measurement
0
1
82
systolic blood pressure
1
69.9
multisite chronic pain
1
29
white matter hyperintensity measurement
1
22.7
platelet crit
1
16.4
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
N-myristoyltransferase 1
VGNC:12504
454744
Macaque
N-myristoyltransferase 1
715885
Mouse
MGI:102579
18107
Rat
RGD:628642
259274
Dog
N-myristoyltransferase 1
VGNC:43866
480494
Species
Name
OMA
EggNOG
Inparanoid
Chimp
N-myristoyltransferase 1
Macaque
N-myristoyltransferase 1
Mouse
Rat
Dog
N-myristoyltransferase 1
Protein Structure (16 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P30419-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 16
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Activation, myristolyation of BID and translocation to mitochondria (R-HSA-75108)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation, myristolyation of BID and translocation to mitochondria
Reactome
Apoptosis
Reactome
Disease
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Activation, myristolyation of BID and translocation to mitochondria
Apoptosis
Disease
G alpha (i) signalling events
GPCR downstream signalling
Protein-Protein Interactions (91)
1 – 10 of 91
CHURC1
Tbio
Novelty: 0.05885372
p_int: 0.999420116
p_ni: 0.000579884
Data Source: BioPlex
GPRC5C
Tbio
Family: GPCR
Novelty: 0.16942353
p_int: 0.999349867
p_ni: 0.000650133
Data Source: BioPlex
NCS1
Tbio
Novelty: 0.0051468
p_int: 0.999150144
p_ni: 0.000849856
Score: 0.286
Data Source: BioPlex,STRINGDB
MARCKSL1
Tbio
Novelty: 0.01290798
p_int: 0.997723288
p_ni: 0.002276712
Data Source: BioPlex
AIFM3
Tbio
Novelty: 0.07970284
p_int: 0.994417826
p_ni: 0.005582174
Score: 0.391
Data Source: BioPlex,STRINGDB
TGFB1
Tchem
Novelty: 0.0001299
p_int: 0.992551132
p_ni: 0.007448868
Score: 0.175
Data Source: BioPlex,STRINGDB
TLDC1
Tdark
Novelty: 0.55979184
p_int: 0.980144756
p_ni: 0.019855244
Score: 0.221
Data Source: BioPlex,STRINGDB
ABLIM1
Tbio
Novelty: 0.05511373
p_int: 0.979166058
p_ni: 0.020833942
Score: 0.21
Data Source: BioPlex,STRINGDB
ANGPTL7
Tbio
Novelty: 0.03893082
p_int: 0.975727712
p_ni: 0.024272288
Score: 0.183
Data Source: BioPlex,STRINGDB
UBTD1
Tdark
Novelty: 0.50393104
p_int: 0.970019294
p_ni: 0.029980706
Data Source: BioPlex
Publication Statistics
PubMed Score  295.18

PubMed score by year
PubTator Score  186.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: