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Tclin
BDKRB2
B2 bradykinin receptor

Protein Summary
Description
Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000539359
  • ENSP00000438376
  • ENSG00000168398
  • ENST00000542454
  • ENSP00000439459
  • ENST00000554311
  • ENSP00000450482

Symbol
  • BKR2
  • B2R
  • BK2
  • BK-2
  • BKR2
  • BRB2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.92
molecular function
0.91
biological process
0.89
ligand (chemical)
0.8
PubMedID
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 328.93   (req: < 5)
Gene RIFs: 151   (req: <= 3)
Antibodies: 233   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 328.93   (req: >= 5)
Gene RIFs: 151   (req: > 3)
Antibodies: 233   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 308
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
1 – 1 of 1
icatibant
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Protein-Protein Interactions (386)
1 – 10 of 386
KNG1
Tbio
Novelty:  0.00007684
Score:  0.997
Data Source:  Reactome,STRINGDB
NOS3
Tchem
Family:  Enzyme
Novelty:  0.00012407
Score:  0.978
Data Source:  STRINGDB
HRH1
Tclin
Family:  GPCR
Novelty:  0.00073548
Score:  0.946
Data Source:  STRINGDB
GNA11
Tchem
Novelty:  0.00128664
Score:  0.944
Data Source:  STRINGDB
TAC1
Tbio
Novelty:  0.00006575
Score:  0.944
Data Source:  STRINGDB
AGTR1
Tclin
Family:  GPCR
Novelty:  0.00033439
Score:  0.944
Data Source:  STRINGDB
GRP
Tbio
Novelty:  0.00034247
Score:  0.94
Data Source:  STRINGDB
BDKRB1
Tchem
Family:  GPCR
Novelty:  0.00625504
Score:  0.938
Data Source:  STRINGDB
AGT
Tbio
Novelty:  0.00049613
Score:  0.933
Data Source:  STRINGDB
GRK2
Tchem
Family:  Kinase
Novelty:  0.00200696
Score:  0.933
Data Source:  STRINGDB
Pathways (25)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (23)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
subcutaneous adipose tissue measurement
1
1
0
232.2
0
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
subcutaneous adipose tissue measurement
0
232.2
0
Find similar targets by:
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:102845
12062
Rat
RGD:2201
25245
Dog
bradykinin receptor B2
VGNC:38425
403658
Cow
bradykinin receptor B2
VGNC:26460
538896
Chicken
bradykinin receptor B2
CGNC:8414
428906
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
bradykinin receptor B2
Cow
bradykinin receptor B2
Chicken
bradykinin receptor B2
Publication Statistics
PubMed Score 328.93
PubMed score by year
PubTator Score 367.45
PubTator score by year
Patents
Patents by year