Tclin BDKRB2 B2 bradykinin receptor

Protein Summary

Description

Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P30411
• B2R

Gene Name

• BDKRB2

Ensembl ID

• ENST00000539359
• ENSP00000438376
• ENSG00000168398
• ENST00000542454
• ENSP00000439459
• ENST00000554311
• ENSP00000450482

Symbol

• BKR2
• B2R
• BK2
• BK-2
• BKR2
• BRB2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.92
molecular function	0.91
biological process	0.89
ligand (chemical)	0.8
PubMedID	0.79

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Bradykinin Receptor / B2 Bradykinin Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 359.37   (req: < 5)

Gene RIFs: 170   (req: <= 3)

Antibodies: 233   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 359.37   (req: >= 5)

Gene RIFs: 170   (req: > 3)

Antibodies: 233   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 308

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1