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Tchem
PPIF
Peptidyl-prolyl cis-trans isomerase F, mitochondrial

Protein Summary
Description
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis. The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the c ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225174
  • ENSP00000225174
  • ENSG00000108179

Symbol
  • CYP3
  • CYP3
  • CypD
  • CyP-M
  • Cyp-D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
transcription factor binding site profile
0.95
biological process
0.93
disease perturbation
0.87
transcription factor perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 729.23   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 357   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 729.23   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 357   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL3344501
chemical structure image
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
4
4
4
90.1
reticulocyte count
4
4
4
68.2
reticulocyte measurement
3
2
3
50.5
heel bone mineral density
2
1
2
30
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
4
90.1
reticulocyte count
4
68.2
reticulocyte measurement
3
50.5
heel bone mineral density
2
30
Protein Data Bank (41)
1 – 5 of 41
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Huntington disease
KEGG
Calcium signaling pathway
KEGG
Toxoplasmosis
KEGG
Parkinson disease
KEGG
cGMP-PKG signaling pathway
Name
Explore in Pharos
Explore in Source
Huntington disease
Calcium signaling pathway
Toxoplasmosis
Parkinson disease
cGMP-PKG signaling pathway
Protein-Protein Interactions (187)
1 – 10 of 187
VDAC1
Tbio
Novelty: 0.0011441
Score: 0.989
Data Source: STRINGDB
VDAC3
Tbio
Novelty: 0.0095068
Score: 0.972
Data Source: STRINGDB
SLC25A4
Tbio
Family: Transporter
Novelty: 0.01250865
Score: 0.969
Data Source: STRINGDB
SLC25A6
Tbio
Family: Transporter
Novelty: 0.0052748
Score: 0.966
Data Source: STRINGDB
SLC25A5
Tbio
Family: Transporter
Novelty: 0.00749909
Score: 0.96
Data Source: STRINGDB
SPG7
Tbio
Family: Enzyme
Novelty: 0.00463357
Score: 0.954
Data Source: STRINGDB
VDAC2
Tchem
Novelty: 0.00575936
Score: 0.935
Data Source: STRINGDB
FKBP1A
Tclin
Family: Enzyme
Novelty: 0.00116174
Score: 0.909
Data Source: STRINGDB
C5
Tclin
Novelty: 0.00225386
Score: 0.901
Data Source: STRINGDB
C8B
Tbio
Novelty: 0.00873524
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  729.23

PubMed score by year
PubTator Score  144.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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