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Tchem
CDC25B
M-phase inducer phosphatase 2

Protein Summary
Description
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity. CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000245960
  • ENSP00000245960
  • ENSG00000101224
  • ENST00000340833
  • ENSP00000339170
  • ENST00000439880
  • ENSP00000405972

Symbol
  • CDC25HU2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase
1
hub protein
0.98
biological term
0.73
transcription factor
0.73
biological process
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 261.97   (req: < 5)
Gene RIFs: 66   (req: <= 3)
Antibodies: 866   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 261.97   (req: >= 5)
Gene RIFs: 66   (req: > 3)
Antibodies: 866   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 54
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
35.7
mean reticulocyte volume
1
1
1
33.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
35.7
mean reticulocyte volume
1
33.2
Protein Data Bank (17)
1 – 5 of 17
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (25)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cyclin A/B1/B2 associated events during G2/M transition
Reactome
Cyclin A:Cdk2-associated events at S phase entry
Reactome
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cyclin A/B1/B2 associated events during G2/M transition
Cyclin A:Cdk2-associated events at S phase entry
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Protein-Protein Interactions (146)
1 – 10 of 146
BTRC
Tbio
Novelty: 0.00293475
p_int: 0.999999992
p_ni: 8e-9
Score: 0.678
Data Source: BioPlex,STRINGDB
FBXW11
Tbio
Novelty: 0.0715377
p_int: 0.999263263
p_ni: 0.000736737
Score: 0.621
Data Source: BioPlex,STRINGDB
YWHAZ
Tbio
Novelty: 0.00210582
p_int: 0.88311909
p_ni: 0.11688091
Score: 0.971
Data Source: BioPlex,STRINGDB
CDK1
Tchem
Family: Kinase
Novelty: 0.00040776
Score: 0.996
Data Source: Reactome,STRINGDB
MAPK14
Tchem
Family: Kinase
Novelty: 0.00045138
Score: 0.992
Data Source: STRINGDB
CCNB1
Tchem
Novelty: 0.0005503
Score: 0.99
Data Source: Reactome,STRINGDB
CHEK1
Tchem
Family: Kinase
Novelty: 0.00066843
Score: 0.989
Data Source: STRINGDB
CDK2
Tchem
Family: Kinase
Novelty: 0.00032118
Score: 0.987
Data Source: STRINGDB
CCNB2
Tbio
Novelty: 0.00672914
Score: 0.985
Data Source: Reactome,STRINGDB
AURKA
Tchem
Family: Kinase
Novelty: 0.0010868
Score: 0.984
Data Source: STRINGDB
Publication Statistics
PubMed Score  261.97

PubMed score by year
PubTator Score  193.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer