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Tchem
CDC25A
M-phase inducer phosphatase 1

Protein Summary
Description
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro. CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302506
  • ENSP00000303706
  • ENSG00000164045
  • ENST00000351231
  • ENSP00000343166

Symbol
  • CDC25A2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase
0.98
hub protein
0.95
histone modification site profile
0.86
transcription factor perturbation
0.84
microRNA
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 375.02   (req: < 5)
Gene RIFs: 107   (req: <= 3)
Antibodies: 1612   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 375.02   (req: >= 5)
Gene RIFs: 107   (req: > 3)
Antibodies: 1612   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 26
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (26)
plumbagin
Rendered image for plumbagin
SID11114132
Rendered image for SID11114132
CHEMBL1765351
Rendered image for CHEMBL1765351
CHEMBL4566962
Rendered image for CHEMBL4566962
SID26514298
Rendered image for SID26514298
CHEMBL4521092
Rendered image for CHEMBL4521092
Shikonin
Rendered image for Shikonin
Protein-Protein Interactions (354)
BTRC
Tbio
Novelty:  0.00293475
p_int:  0.999990568
p_ni:  0.000009432
p_wrong:  1e-9
Score:  0.745
Data Source:  BioPlex,STRINGDB
FBXW11
Tbio
Novelty:  0.0715377
p_int:  0.999445116
p_ni:  0.000554884
Score:  0.607
Data Source:  BioPlex,STRINGDB
UBE4B
Tbio
Novelty:  0.01396546
p_int:  0.999266156
p_ni:  0.000733841
p_wrong:  3e-9
Score:  0.252
Data Source:  BioPlex,STRINGDB
YWHAZ
Tchem
Novelty:  0.00210582
p_int:  0.81309756
p_ni:  0.18690244
Score:  0.705
Data Source:  BioPlex,STRINGDB
CHEK1
Tchem
Family:  Kinase
Novelty:  0.00066843
Score:  0.999
Data Source:  Reactome,STRINGDB
CDK1
Tchem
Family:  Kinase
Novelty:  0.00040776
Score:  0.998
Data Source:  Reactome,STRINGDB
CCNB1
Tchem
Novelty:  0.0005503
Score:  0.998
Data Source:  Reactome,STRINGDB
CHEK2
Tchem
Family:  Kinase
Novelty:  0.00068355
Score:  0.997
Data Source:  Reactome,STRINGDB
CDK2
Tchem
Family:  Kinase
Novelty:  0.00032118
Score:  0.996
Data Source:  Reactome,STRINGDB
CCNA2
Tchem
Novelty:  0.00049887
Score:  0.99
Data Source:  STRINGDB
Pathways (47)
Activation of ATR in response to replication stress (R-HSA-176187)

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Find Similar Targets
Items per page:
1 – 5 of 28
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of ATR in response to replication stress
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Reactome
Cyclin A/B1/B2 associated events during G2/M transition
Name
Explore in Pharos
Explore in Source
Activation of ATR in response to replication stress
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Cyclin A/B1/B2 associated events during G2/M transition
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
macrophage inflammatory protein 1b measurement
1
1
1
78.5
high density lipoprotein cholesterol measurement
3
2
3
75.6
BMI-adjusted waist circumference
1
1
1
48.5
waist circumference
1
1
1
39.6
diastolic blood pressure
1
1
1
27.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
macrophage inflammatory protein 1b measurement
1
78.5
high density lipoprotein cholesterol measurement
3
75.6
BMI-adjusted waist circumference
1
48.5
waist circumference
1
39.6
diastolic blood pressure
1
27.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cell division cycle 25A
VGNC:1770
460341
Macaque
M-phase inducer phosphatase 1
710858
Mouse
MGI:103198
12530
Rat
RGD:621498
171102
Dog
cell division cycle 25A
VGNC:38989
484780
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cell division cycle 25A
Macaque
M-phase inducer phosphatase 1
Mouse
Rat
Dog
cell division cycle 25A
Publication Statistics
PubMed Score 375.02
PubMed score by year
PubTator Score 286.36
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title