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Tchem
CDC25A
M-phase inducer phosphatase 1

Protein Summary
Description
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro. CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302506
  • ENSP00000303706
  • ENSG00000164045
  • ENST00000351231
  • ENSP00000343166

Symbol
  • CDC25A2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase
0.98
hub protein
0.95
histone modification site profile
0.86
transcription factor perturbation
0.84
microRNA
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 368.03   (req: < 5)
Gene RIFs: 107   (req: <= 3)
Antibodies: 1612   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 368.03   (req: >= 5)
Gene RIFs: 107   (req: > 3)
Antibodies: 1612   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 19
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
1
1
79
macrophage inflammatory protein 1b measurement
1
1
1
75.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
79
macrophage inflammatory protein 1b measurement
1
75.1
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cell division cycle 25A
VGNC:1770
460341
Macaque
M-phase inducer phosphatase 1
710858
Mouse
MGI:103198
12530
Rat
RGD:621498
171102
Dog
cell division cycle 25A
VGNC:38989
484780
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cell division cycle 25A
Macaque
M-phase inducer phosphatase 1
Mouse
Rat
Dog
cell division cycle 25A
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P30304-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (47)
Activation of ATR in response to replication stress (R-HSA-176187)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 28
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of ATR in response to replication stress
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Reactome
Cyclin A/B1/B2 associated events during G2/M transition
Name
Explore in Pharos
Explore in Source
Activation of ATR in response to replication stress
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Cyclin A/B1/B2 associated events during G2/M transition
Protein-Protein Interactions (354)
1 – 10 of 354
BTRC
Tbio
Novelty: 0.00293475
p_int: 0.999990568
p_ni: 0.000009432
p_wrong: 1e-9
Score: 0.745
Data Source: BioPlex,STRINGDB
FBXW11
Tbio
Novelty: 0.0715377
p_int: 0.999445116
p_ni: 0.000554884
Score: 0.607
Data Source: BioPlex,STRINGDB
UBE4B
Tbio
Novelty: 0.01396546
p_int: 0.999266156
p_ni: 0.000733841
p_wrong: 3e-9
Score: 0.252
Data Source: BioPlex,STRINGDB
YWHAZ
Tbio
Novelty: 0.00210582
p_int: 0.81309756
p_ni: 0.18690244
Score: 0.705
Data Source: BioPlex,STRINGDB
CHEK1
Tchem
Family: Kinase
Novelty: 0.00066843
Score: 0.999
Data Source: Reactome,STRINGDB
CDK1
Tchem
Family: Kinase
Novelty: 0.00040776
Score: 0.998
Data Source: Reactome,STRINGDB
CCNB1
Tchem
Novelty: 0.0005503
Score: 0.998
Data Source: Reactome,STRINGDB
CHEK2
Tchem
Family: Kinase
Novelty: 0.00068355
Score: 0.997
Data Source: Reactome,STRINGDB
CDK2
Tchem
Family: Kinase
Novelty: 0.00032118
Score: 0.996
Data Source: Reactome,STRINGDB
CCNA2
Tchem
Novelty: 0.00049887
Score: 0.99
Data Source: STRINGDB
Publication Statistics
PubMed Score  368.03

PubMed score by year
PubTator Score  286.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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