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Tchem
WEE1
Wee1-like protein kinase

Protein Summary
Description
Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation. This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus fro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299613
  • ENSP00000299613
  • ENSG00000166483
  • ENST00000450114
  • ENSP00000402084

Symbol
  • WEE1A
  • WEE1hu
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
PubMedID
0.94
transcription factor binding site profile
0.92
hub protein
0.9
kinase
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 724.75   (req: < 5)
Gene RIFs: 85   (req: <= 3)
Antibodies: 594   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 724.75   (req: >= 5)
Gene RIFs: 85   (req: > 3)
Antibodies: 594   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 153
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0