Tchem WEE1 Wee1-like protein kinase

Protein Summary

Description

Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation. This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P30291
• B3KVE1
• D3DQV0
• WEE1hu

Gene Name

• WEE1

Ensembl ID

• ENST00000299613
• ENSP00000299613
• ENSG00000166483
• ENST00000450114
• ENSP00000402084

Symbol

• WEE1A
• WEE1hu

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.96
PubMedID	0.94
transcription factor binding site profile	0.92
hub protein	0.9
kinase	0.88

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Wee1-like Protein Kinase

DTO Classes

Protein / Kinase / Protein Kinase / Other Group / Wee Family / Wee1-like Protein Kinase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 724.75   (req: < 5)

Gene RIFs: 85   (req: <= 3)

Antibodies: 594   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 724.75   (req: >= 5)

Gene RIFs: 85   (req: > 3)

Antibodies: 594   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 153

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0