Protein Summary
Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation. This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus fro ...more
- ENST00000299613
- ENSP00000299613
- ENSG00000166483
- ENST00000450114
- ENSP00000402084
- WEE1A
- WEE1hu
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.96 | ||
PubMedID | 0.94 | ||
transcription factor binding site profile | 0.92 | ||
hub protein | 0.9 | ||
kinase | 0.88 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 662.16 (req: < 5)
Gene RIFs: 85 (req: <= 3)
Antibodies: 594 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 662.16 (req: >= 5)
Gene RIFs: 85 (req: > 3)
Antibodies: 594 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 94
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (94)
Protein-Protein Interactions (203)
YEATS4
Novelty: 0.02632024
p_int: 0.999997788
p_ni: 0.000002032
p_wrong: 1.8e-7
Score: 0.211
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (70)
Reactome (18)
KEGG (2)
PathwayCommons (6)
WikiPathways (44)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle Checkpoints | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | ||||
Reactome | Cyclin A/B1/B2 associated events during G2/M transition | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell Cycle | ||||
Cell Cycle Checkpoints | ||||
Cell Cycle, Mitotic | ||||
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | ||||
Cyclin A/B1/B2 associated events during G2/M transition | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (6)
Components (4)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body height | 1 | 1 | 1 | 74.4 | |||||
HbA1c measurement | 1 | 1 | 1 | 17.8 | |||||
cutaneous squamous cell carcinoma | 1 | 1 | 1 | 11.5 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body height | 1 | 74.4 | |||||
HbA1c measurement | 1 | 17.8 | |||||
cutaneous squamous cell carcinoma | 1 | 11.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | WEE1 G2 checkpoint kinase | VGNC:939 | 466440 | |||||
Macaque | WEE1 G2 checkpoint kinase | 703760 | ||||||
Mouse | MGI:103075 | 22390 | ||||||
Rat | RGD:1307895 | 308937 | ||||||
Dog | WEE1 G2 checkpoint kinase | VGNC:48402 | 476847 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | WEE1 G2 checkpoint kinase | |||||
Macaque | WEE1 G2 checkpoint kinase | |||||
Mouse | ||||||
Rat | ||||||
Dog | WEE1 G2 checkpoint kinase | |||||
Publication Statistics
PubMed Score 662.16
PubMed score by year
PubTator Score 258.77
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (121)
GeneRif Annotations (85)
Items per page:
0 of 0
PMID | Year | Title |
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