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Tchem
WEE1
Wee1-like protein kinase

Protein Summary
Description
Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation. This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus fro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299613
  • ENSP00000299613
  • ENSG00000166483
  • ENST00000450114
  • ENSP00000402084

Symbol
  • WEE1A
  • WEE1hu
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
PubMedID
0.94
transcription factor binding site profile
0.92
hub protein
0.9
kinase
0.88


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 662.16   (req: < 5)
Gene RIFs: 85   (req: <= 3)
Antibodies: 594   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 662.16   (req: >= 5)
Gene RIFs: 85   (req: > 3)
Antibodies: 594   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 94
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
74.4
HbA1c measurement
1
1
1
17.8
cutaneous squamous cell carcinoma
1
1
1
11.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
74.4
HbA1c measurement
1
17.8
cutaneous squamous cell carcinoma
1
11.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WEE1 G2 checkpoint kinase
VGNC:939
466440
Macaque
WEE1 G2 checkpoint kinase
703760
Mouse
MGI:103075
22390
Rat
RGD:1307895
308937
Dog
WEE1 G2 checkpoint kinase
VGNC:48402
476847
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WEE1 G2 checkpoint kinase
Macaque
WEE1 G2 checkpoint kinase
Mouse
Rat
Dog
WEE1 G2 checkpoint kinase
Protein Structure (20 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P30291-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 20
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (70)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Reactome
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Reactome
Cyclin A/B1/B2 associated events during G2/M transition
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Cyclin A/B1/B2 associated events during G2/M transition
Gene Ontology Terms (17)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (203)
1 – 10 of 203
YEATS4
Tbio
Novelty:  0.02632024
p_int:  0.999997788
p_ni:  0.000002032
p_wrong:  1.8e-7
Score:  0.211
Data Source:  BioPlex,STRINGDB
CDK1
Tchem
Family:  Kinase
Novelty:  0.00040776
Score:  0.998
Data Source:  Reactome,STRINGDB
CDC25C
Tchem
Family:  Enzyme
Novelty:  0.00227769
Score:  0.99
Data Source:  STRINGDB
CDC25A
Tchem
Family:  Enzyme
Novelty:  0.00250149
Score:  0.987
Data Source:  STRINGDB
CCNB1
Tchem
Novelty:  0.0005503
Score:  0.987
Data Source:  Reactome,STRINGDB
CCNA2
Tchem
Novelty:  0.00049887
Score:  0.98
Data Source:  STRINGDB
CDK2
Tchem
Family:  Kinase
Novelty:  0.00032118
Score:  0.973
Data Source:  Reactome,STRINGDB
PLK1
Tchem
Family:  Kinase
Novelty:  0.00062799
Score:  0.97
Data Source:  Reactome,STRINGDB
CCNE1
Tchem
Novelty:  0.00237201
Score:  0.964
Data Source:  STRINGDB
CCNE2
Tbio
Novelty:  0.00795182
Score:  0.962
Data Source:  STRINGDB
Publication Statistics
PubMed Score  662.16

PubMed score by year
PubTator Score  258.77

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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