Tchem CCND3 G1/S-specific cyclin-D3

Protein Summary

Description

Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• P30281
• B2RD63
• B3KQ22
• E9PAS4
• E9PB36
• Q5T8J0
• Q6FG62
• Q96F49

Gene Name

• CCND3

Ensembl ID

• ENST00000372988
• ENSP00000362079
• ENSG00000112576
• ENST00000372991
• ENSP00000362082
• ENST00000414200
• ENSP00000397545
• ENST00000415497
• ENSP00000401595
• ENST00000511642
• ENSP00000426212
• ENST00000616010
• ENSP00000484424

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.97
transcription factor perturbation	0.97
PubMedID	0.96
transcription factor binding site profile	0.93
chemical	0.91

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / G1/s-specific Cyclin-d3

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / G1/s-specific Cyclin-d3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 418.61   (req: < 5)

Gene RIFs: 100   (req: <= 3)

Antibodies: 756   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 418.61   (req: >= 5)

Gene RIFs: 100   (req: > 3)

Antibodies: 756   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0