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Tchem
CCND3
G1/S-specific cyclin-D3

Protein Summary
Description
Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the ce ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372988
  • ENSP00000362079
  • ENSG00000112576
  • ENST00000372991
  • ENSP00000362082
  • ENST00000414200
  • ENSP00000397545
  • ENST00000415497
  • ENSP00000401595
  • ENST00000511642
  • ENSP00000426212
  • ENST00000616010
  • ENSP00000484424
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
transcription factor perturbation
0.97
PubMedID
0.96
transcription factor binding site profile
0.93
chemical
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 392.41   (req: < 5)
Gene RIFs: 90   (req: <= 3)
Antibodies: 756   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 392.41   (req: >= 5)
Gene RIFs: 90   (req: > 3)
Antibodies: 756   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (178)
CDK6
Tclin
Family:  Kinase
Novelty:  0.00109319
p_int:  0.999999998
p_ni:  2e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
CDKN1B
Tbio
Family:  Enzyme
Novelty:  0.00069449
p_int:  0.999999932
p_ni:  6.8e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
CDK4
Tclin
Family:  Kinase
Novelty:  0.00036742
p_int:  0.999999792
p_ni:  2.08e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
CDKN1C
Tbio
Family:  Enzyme
Novelty:  0.00220485
p_int:  0.999999713
p_ni:  2.27e-7
p_wrong:  6e-8
Score:  0.991
Data Source:  BioPlex,STRINGDB
RBL2
Tbio
Novelty:  0.00121893
p_int:  0.999995754
p_ni:  0.000004245
Score:  0.99
Data Source:  BioPlex,STRINGDB
CDKN1A
Tchem
Family:  Enzyme
Novelty:  0.00033009
p_int:  0.999956785
p_ni:  8.64e-7
p_wrong:  0.000042351
Score:  0.999
Data Source:  BioPlex,STRINGDB
CDKN2C
Tbio
Family:  Enzyme
Novelty:  0.00806886
p_int:  0.999916215
p_ni:  0.000072109
p_wrong:  0.000011676
Score:  0.991
Data Source:  BioPlex,STRINGDB
KLK5
Tchem
Family:  Enzyme
Novelty:  0.00835407
p_int:  0.999851267
p_ni:  0.00013718
p_wrong:  0.000011553
Data Source:  BioPlex
CDK2
Tchem
Family:  Kinase
Novelty:  0.00032118
p_int:  0.99931555
p_ni:  0.000684449
Score:  0.999
Data Source:  BioPlex,STRINGDB
CDK5
Tchem
Family:  Kinase
Novelty:  0.00071394
p_int:  0.996607531
p_ni:  0.003392469
Score:  0.696
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (5)
Explore Nearest Tclin Targets
1 – 3 of 3
CDK4
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  11
more:  7 more common pathways
GSK3B
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  8
more:  4 more common pathways
CDK6
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  10
more:  6 more common pathways
Pathways (53)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cyclin D associated events in G1
Reactome
Developmental Biology
Reactome
G1 Phase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cyclin D associated events in G1
Developmental Biology
G1 Phase
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (30)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
6
14
18
99.9
mean reticulocyte volume
1
10
10
99.8
reticulocyte count
5
7
15
99.3
red blood cell distribution width
4
6
11
99.2
mean corpuscular hemoglobin
4
5
6
98.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
18
99.9
mean reticulocyte volume
10
99.8
reticulocyte count
15
99.3
red blood cell distribution width
11
99.2
mean corpuscular hemoglobin
6
98.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin D3
VGNC:11040
462689
Macaque
cyclin D3
695215
Mouse
MGI:88315
12445
Rat
RGD:2293
25193
Dog
cyclin D3
VGNC:54284
608847
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin D3
Macaque
cyclin D3
Mouse
Rat
Dog
cyclin D3
Publication Statistics
PubMed Score 392.41
PubMed score by year
PubTator Score 322.54
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title