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Tbio
CCND2
G1/S-specific cyclin-D2

Protein Summary
Description
Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity). The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundanc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261254
  • ENSP00000261254
  • ENSG00000118971

Symbol
  • MPPH3
  • KIAK0002
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
transcription factor perturbation
1
gene perturbation
0.99
kinase perturbation
0.97
virus perturbation
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 569.37   (req: < 5)
Gene RIFs: 115   (req: <= 3)
Antibodies: 720   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 569.37   (req: >= 5)
Gene RIFs: 115   (req: > 3)
Antibodies: 720   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
1
6
98.1
4
4
2
1.4
98
appendicular lean mass
3
1
3
97.8
2
2
0
1.1
97
low density lipoprotein cholesterol measurement
2
1
2
94.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
98.1
2
1.4
98
appendicular lean mass
3
97.8
0
1.1
97
low density lipoprotein cholesterol measurement
2
94.3
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (52)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cyclin D associated events in G1
Reactome
G1 Phase
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cyclin D associated events in G1
G1 Phase
Gene expression (Transcription)
Protein-Protein Interactions (238)
1 – 10 of 238
CDKN1A
Tbio
Family: Enzyme
Novelty: 0.00033009
p_int: 0.999999524
p_ni: 3.33e-7
p_wrong: 1.44e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
CDKN1B
Tbio
Family: Enzyme
Novelty: 0.00069449
p_int: 0.999995861
p_ni: 0.000004139
Score: 0.996
Data Source: BioPlex,STRINGDB
CDKN1C
Tbio
Family: Enzyme
Novelty: 0.00220485
p_int: 0.999835629
p_ni: 0.000001221
p_wrong: 0.000163151
Score: 0.986
Data Source: BioPlex,STRINGDB
CDK4
Tclin
Family: Kinase
Novelty: 0.00036742
p_int: 0.997043959
p_ni: 0.002956041
Score: 0.999
Data Source: BioPlex,STRINGDB
RBL2
Tbio
Novelty: 0.00121893
p_int: 0.994564353
p_ni: 0.005419532
p_wrong: 0.000016114
Score: 0.992
Data Source: BioPlex,STRINGDB
CDK2
Tchem
Family: Kinase
Novelty: 0.00032118
p_int: 0.964921405
p_ni: 0.035078595
Score: 0.995
Data Source: BioPlex,STRINGDB
CDK5
Tchem
Family: Kinase
Novelty: 0.00071394
p_int: 0.958410106
p_ni: 0.041589894
Score: 0.848
Data Source: BioPlex,STRINGDB
CDK6
Tclin
Family: Kinase
Novelty: 0.00109319
Score: 0.996
Data Source: STRINGDB
RB1
Tchem
Novelty: 0.00063798
Score: 0.986
Data Source: STRINGDB
CDK1
Tchem
Family: Kinase
Novelty: 0.00040776
Score: 0.979
Data Source: STRINGDB
Publication Statistics
PubMed Score  569.37

PubMed score by year
PubTator Score  363.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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