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Tbio
FCER1G
High affinity immunoglobulin epsilon receptor subunit gamma

Protein Summary
Description
Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils, priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functional signaling complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. May function cooperatively with other activating receptors. Functionally linked to integrin b ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000289902
  • ENSP00000289902
  • ENSG00000158869

Symbol
  • FCRG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
gene perturbation
0.76
kinase perturbation
0.76
tissue sample
0.64
phenotype
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.39   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.39   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 44
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
2
0
1.1
94.8
mean platelet volume
3
2
4
88.8
Eczema
2
1
0
1
81.5
4
1
0
1
73.2
childhood onset asthma
1
1
0
1.1
68.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
94.8
mean platelet volume
4
88.8
Eczema
0
1
81.5
0
1
73.2
childhood onset asthma
0
1.1
68.2
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Fc fragment of IgE receptor Ig
VGNC:6818
100612300
Macaque
Fc fragment of IgE receptor Ig
720291
Mouse
MGI:95496
14127
Rat
RGD:2599
25441
Dog
Fc fragment of IgE receptor Ig
VGNC:40802
403798
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Fc fragment of IgE receptor Ig
Macaque
Fc fragment of IgE receptor Ig
Mouse
Rat
Dog
Fc fragment of IgE receptor Ig
Pathways (28)
C-type lectin receptors (CLRs) (R-HSA-5621481)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
C-type lectin receptors (CLRs)
Reactome
Cell surface interactions at the vascular wall
Reactome
Dectin-2 family
Reactome
Fc epsilon receptor (FCERI) signaling
Reactome
GPVI-mediated activation cascade
Name
Explore in Pharos
Explore in Source
C-type lectin receptors (CLRs)
Cell surface interactions at the vascular wall
Dectin-2 family
Fc epsilon receptor (FCERI) signaling
GPVI-mediated activation cascade
Gene Ontology Terms (51)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (219)
1 – 10 of 219
SYK
Tclin
Family: Kinase
Novelty: 0.00058994
Score: 0.988
Data Source: Reactome,STRINGDB
FCER1A
Tbio
Novelty: 0.00362182
Score: 0.984
Data Source: Reactome,STRINGDB
GP6
Tbio
Novelty: 0.0010722
Score: 0.976
Data Source: Reactome,STRINGDB
ITGB2
Tclin
Novelty: 0.00185859
Score: 0.973
Data Source: STRINGDB
PLCG2
Tchem
Family: Enzyme
Novelty: 0.00294726
Score: 0.973
Data Source: Reactome,STRINGDB
LYN
Tclin
Family: Kinase
Novelty: 0.00097393
Score: 0.973
Data Source: Reactome,STRINGDB
FCGR2B
Tbio
Novelty: 0.00098166
Score: 0.972
Data Source: STRINGDB
FCGR3A
Tbio
Novelty: 0.0004214
Score: 0.97
Data Source: STRINGDB
FCAR
Tbio
Novelty: 0.00436414
Score: 0.966
Data Source: STRINGDB
CLEC4E
Tchem
Novelty: 0.00793367
Score: 0.965
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  103.39

PubMed score by year
PubTator Score  117.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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