Tbio CDC27 Cell division cycle protein 27 homolog

Protein Summary

Description

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate, which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three other members of the APC complex contain tetratricopeptide (TPR) repeats, which are important for protein-protein interactions. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and it may thus be involved in controlling the timing of mitosis. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 22 and Y. [provided by RefSeq, May 2014]

Uniprot Accession IDs

• P30260
• G3V1C4
• Q16349
• Q96F35

Gene Name

• CDC27

Ensembl ID

• ENST00000066544
• ENSP00000066544
• ENSG00000004897
• ENST00000531206
• ENSP00000434614

Symbol

• ANAPC3
• D0S1430E
• D17S978E
• APC3
• HNUC
• NUC2
• H-NUC
• ANAPC3
• CDC27Hs
• D0S1430E
• D17S978E

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.99
transcription factor perturbation	0.96
biological process	0.94
interacting protein	0.94
histone modification site profile	0.92

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.9   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 452   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.9   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 452   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GlyGen

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ARCHS4

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (527)

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1 – 10 of 527

• See Interactions on String-DB

ANAPC16

Tdark

Family:  Enzyme

Novelty:  0.06353035

p_int:  0.999999777

p_ni:  2.18e-7

p_wrong:  5e-9

Score:  0.999

Data Source:  BioPlex,STRINGDB

ANAPC5

Tbio

Family:  Enzyme

Novelty:  0.02102572

p_int:  0.999999549

p_ni:  4.51e-7

Score:  0.999

Data Source:  BioPlex,STRINGDB

ANAPC13

Tbio

Family:  Enzyme

Novelty:  0.06125489

p_int:  0.999998604

p_ni:  0.000001395

Score:  0.999

Data Source:  BioPlex,STRINGDB

CDC26

Tbio

Family:  Enzyme

Novelty:  0.07456358

p_int:  0.999998104

p_ni:  0.000001896

Score:  0.999

Data Source:  BioPlex,STRINGDB

C16orf87

Tdark

Novelty:  5.71664261

p_int:  0.999969623

p_ni:  0.000030377

Score:  0.392

Data Source:  BioPlex,STRINGDB

GRAP2

Tbio

Novelty:  0.00503901

p_int:  0.999922559

p_ni:  0.000077441

Data Source:  BioPlex

MAGIX

Tdark

Novelty:  0.38577176

p_int:  0.999878297

p_ni:  0.000121698

p_wrong:  5e-9

Score:  0.173

Data Source:  BioPlex,STRINGDB

TTLL1

Tdark

Family:  Enzyme

Novelty:  0.09244899

p_int:  0.999741982

p_ni:  0.000257935

p_wrong:  8.3e-8

Score:  0.197

Data Source:  BioPlex,STRINGDB

ANO6

Tbio

Family:  IC

Novelty:  0.01288434

p_int:  0.999395078

p_ni:  0.000604922

Data Source:  BioPlex

CDC16

Tbio

Novelty:  0.00916715

p_int:  0.999142349

p_ni:  0.000857646

p_wrong:  5e-9

Score:  0.999

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets (3)

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Upstream (3)

1 – 3 of 3

CALM1

Tclin

Family:  Other

KEGG Distance:  4

Common Pathways:  1

1: Oocyte meiosis

CALM3

Tclin

Family:  Other

KEGG Distance:  4

Common Pathways:  1

1: Oocyte meiosis

CALM2

Tclin

Family:  Other

KEGG Distance:  4

Common Pathways:  1

1: Oocyte meiosis

Pathways (56)

Reactome (37)

KEGG (5)

PathwayCommons (1)

UniProt (1)

WikiPathways (12)

APC-Cdc20 mediated degradation of Nek2A (R-HSA-179409)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	APC-Cdc20 mediated degradation of Nek2A	25 targets	R-HSA-179409
Reactome	APC/C-mediated degradation of cell cycle proteins	87 targets	R-HSA-174143
Reactome	APC/C:Cdc20 mediated degradation of Cyclin B	23 targets	R-HSA-174048
Reactome	APC/C:Cdc20 mediated degradation of Securin	68 targets	R-HSA-174154
Reactome	APC/C:Cdc20 mediated degradation of mitotic proteins	76 targets	R-HSA-176409

Name	Explore in Pharos	Explore in Source
APC-Cdc20 mediated degradation of Nek2A	25 targets	R-HSA-179409
APC/C-mediated degradation of cell cycle proteins	87 targets	R-HSA-174143
APC/C:Cdc20 mediated degradation of Cyclin B	23 targets	R-HSA-174048
APC/C:Cdc20 mediated degradation of Securin	68 targets	R-HSA-174154
APC/C:Cdc20 mediated degradation of mitotic proteins	76 targets	R-HSA-176409

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (13)

Functions (1)

Components (7)

Processes (5)

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1 – 1 of 1

GO Term	Evidence	Assigned by
protein phosphatase binding	Inferred from Physical Interaction (IPI)	BHF-UCL

Disease Associations ()

No disease associations found

GWAS Traits (10)

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5

1 – 5 of 10

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
platelet count	EFO_0004309	1	1	1		63.7
serum non-albumin protein measurement	EFO_0004568	1	2	2		57.7
serum urea measurement	EFO_0009795	1	1	1		55.2
eosinophil count	EFO_0004842	1	1	1		44.2
eosinophil percentage of leukocytes	EFO_0007991	1	1	1		39.6

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5

1 – 5 of 10

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
platelet count	EFO_0004309	1		63.7
serum non-albumin protein measurement	EFO_0004568	2		57.7
serum urea measurement	EFO_0009795	1		55.2
eosinophil count	EFO_0004842	1		44.2
eosinophil percentage of leukocytes	EFO_0007991	1		39.6

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Complete proteome
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Repeat
TPR repeat
Ubl conjugation pathway

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted hip circumference
body mass index
eosinophil count
eosinophil percentage of leukocytes
hematocrit
mean platelet volume
platelet count
serum non-albumin protein measurement
serum urea measurement
Thyroid preparation use measurement

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	cell division cycle 27	VGNC:12048	454815
Macaque	cell division cycle 27		717321
Mouse	cell division cycle 27	MGI:102685	217232
Rat	cell division cycle 27	RGD:1304921	360643
Dog	cell division cycle 27	VGNC:53202	490924

Species	Name	OMA	EggNOG	Inparanoid
Chimp	cell division cycle 27
Macaque	cell division cycle 27
Mouse	cell division cycle 27
Rat	cell division cycle 27
Dog	cell division cycle 27

Publication Statistics

PubMed Score 169.90

PubMed score by year

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PubTator Score 74.43

PubTator score by year

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Related Publications

Text Mined References (90)

GeneRif Annotations (18)

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PMID	Year	Title