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Tbio
CDC27
Cell division cycle protein 27 homolog

Protein Summary
Description
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate, which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three other members of the APC complex contain t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000066544
  • ENSP00000066544
  • ENSG00000004897
  • ENST00000531206
  • ENSP00000434614

Symbol
  • ANAPC3
  • D0S1430E
  • D17S978E
  • APC3
  • HNUC
  • NUC2
  • H-NUC
  • ANAPC3
  • CDC27Hs
  • D0S1430E
  • D17S978E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.99
transcription factor perturbation
0.96
biological process
0.94
interacting protein
0.94
histone modification site profile
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.81   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 452   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.81   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 452   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (13)
1 – 5 of 13
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (56)
APC-Cdc20 mediated degradation of Nek2A (R-HSA-179409)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 37
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
APC-Cdc20 mediated degradation of Nek2A
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Cyclin B
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
APC-Cdc20 mediated degradation of Nek2A
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Cyclin B
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Protein-Protein Interactions (527)
1 – 10 of 527
ANAPC16
Tdark
Family: Enzyme
Novelty: 0.09302326
p_int: 0.999999777
p_ni: 2.18e-7
p_wrong: 5e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
ANAPC5
Tbio
Family: Enzyme
Novelty: 0.0345899
p_int: 0.999999549
p_ni: 4.51e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
ANAPC13
Tbio
Family: Enzyme
Novelty: 0.0994907
p_int: 0.999998604
p_ni: 0.000001395
Score: 0.999
Data Source: BioPlex,STRINGDB
CDC26
Tbio
Family: Enzyme
Novelty: 0.12631579
p_int: 0.999998104
p_ni: 0.000001896
Score: 0.999
Data Source: BioPlex,STRINGDB
C16orf87
Tdark
p_int: 0.999969623
p_ni: 0.000030377
Score: 0.392
Data Source: BioPlex,STRINGDB
GRAP2
Tbio
Novelty: 0.00186531
p_int: 0.999922559
p_ni: 0.000077441
Data Source: BioPlex
MAGIX
Tdark
Novelty: 0.09090909
p_int: 0.999878297
p_ni: 0.000121698
p_wrong: 5e-9
Score: 0.173
Data Source: BioPlex,STRINGDB
TTLL1
Tdark
Family: Enzyme
Novelty: 0.14944557
p_int: 0.999741982
p_ni: 0.000257935
p_wrong: 8.3e-8
Score: 0.197
Data Source: BioPlex,STRINGDB
ANO6
Tbio
Family: IC
Novelty: 0.01570866
p_int: 0.999395078
p_ni: 0.000604922
Data Source: BioPlex
CDC16
Tbio
Novelty: 0.01336597
p_int: 0.999142349
p_ni: 0.000857646
p_wrong: 5e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  98.81

PubMed score by year
PubTator Score  74.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer