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Tbio
CD6
T-cell differentiation antigen CD6

Protein Summary
Description
Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 (PubMed:15048703, PubMed:15294938, PubMed:16352806, PubMed:16914752, PubMed:24945728, PubMed:24584089). Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089). Functions as costimulatory molecule; promotes T-cell activation and proliferation (PubMed:15294938, PubMed:16352806, PubMed:16914752). Contributes to the formation and maturation of the immunological synapse (PubMed:15294938, PubMed:16352806). Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria (PubMed:17601777). LPS binding leads to the activation of signaling cascades and down-stream MAP kinases (PubMed:17601777). Mediates activation of the inflammatory response and the secretion of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313421
  • ENSP00000323280
  • ENSG00000013725
  • ENST00000352009
  • ENSP00000340628
  • ENST00000452451
  • ENSP00000390676

Symbol
  • TP120
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
co-expressed gene
0.82
tissue sample
0.74
gene perturbation
0.72
transcription factor perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 332.66   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 1133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 332.66   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 1133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (57)
ALCAM
Tbio
Novelty:  0.00244371
Score:  0.984
Data Source:  STRINGDB
CD2
Tclin
Novelty:  0.00037283
Score:  0.89
Data Source:  STRINGDB
CD5
Tbio
Novelty:  0.00032883
Score:  0.867
Data Source:  STRINGDB
LCP2
Tbio
Novelty:  0.00512968
Score:  0.792
Data Source:  STRINGDB
SLC15A3
Tbio
Family:  Transporter
Novelty:  0.02161979
Score:  0.756
Data Source:  STRINGDB
SDCBP
Tbio
Novelty:  0.00242211
Score:  0.723
Data Source:  STRINGDB
CD7
Tbio
Novelty:  0.00107937
Score:  0.711
Data Source:  STRINGDB
ANKRD11
Tbio
Novelty:  0.01106723
Score:  0.7
Data Source:  STRINGDB
SKAP1
Tbio
Family:  Enzyme
Novelty:  0.03753848
Score:  0.647
Data Source:  STRINGDB
SEZ6
Tdark
Novelty:  0.08595944
Score:  0.643
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
4
0
1.1
92.5
cathepsin L1 measurement
1
1
1
77.3
CD6 measurement
1
1
1
67.3
2
1
0
1.1
61.4
eosinophil count
3
3
3
60.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
92.5
cathepsin L1 measurement
1
77.3
CD6 measurement
1
67.3
0
1.1
61.4
eosinophil count
3
60.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD6 molecule
VGNC:3156
451230
Mouse
MGI:103566
12511
Rat
RGD:2312
25752
Dog
CD6 molecule
VGNC:38966
483804
Horse
CD6 molecule
VGNC:16274
100062081
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD6 molecule
Mouse
Rat
Dog
CD6 molecule
Horse
CD6 molecule
Publication Statistics
PubMed Score 332.66
PubMed score by year
PubTator Score 767.11
PubTator score by year
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Related Publications
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PMID
Year
Title